Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models

Matrix metalloproteinase-12 (Mmp12) is upregulated by cigarette smoke (CS) and plays a critical role in extracellular matrix remodeling, a key mechanism involved in physiological repair processes, and in the pathogenesis of emphysema, asthma, and lung cancer. While cigarette smoking is associated wi...

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Detalles Bibliográficos
Autores principales: Noël, Alexandra, Perveen, Zakia, Xiao, Rui, Hammond, Harriet, Le Donne, Viviana, Legendre, Kelsey, Gartia, Manas Ranjan, Sahu, Sushant, Paulsen, Daniel B., Penn, Arthur L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667558/
https://www.ncbi.nlm.nih.gov/pubmed/34912233
http://dx.doi.org/10.3389/fphys.2021.704401

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