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Translational Control in Liver Disease

Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic facto...

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Detalles Bibliográficos
Autores principales: Balvey, Alexandra, Fernandez, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667601/
https://www.ncbi.nlm.nih.gov/pubmed/34912244
http://dx.doi.org/10.3389/fphys.2021.795298
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author Balvey, Alexandra
Fernandez, Mercedes
author_facet Balvey, Alexandra
Fernandez, Mercedes
author_sort Balvey, Alexandra
collection PubMed
description Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.
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spelling pubmed-86676012021-12-14 Translational Control in Liver Disease Balvey, Alexandra Fernandez, Mercedes Front Physiol Physiology Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8667601/ /pubmed/34912244 http://dx.doi.org/10.3389/fphys.2021.795298 Text en Copyright © 2021 Balvey and Fernandez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Balvey, Alexandra
Fernandez, Mercedes
Translational Control in Liver Disease
title Translational Control in Liver Disease
title_full Translational Control in Liver Disease
title_fullStr Translational Control in Liver Disease
title_full_unstemmed Translational Control in Liver Disease
title_short Translational Control in Liver Disease
title_sort translational control in liver disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667601/
https://www.ncbi.nlm.nih.gov/pubmed/34912244
http://dx.doi.org/10.3389/fphys.2021.795298
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