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Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR...

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Detalles Bibliográficos
Autores principales: Bodinier, Maxime, Peronnet, Estelle, Brengel-Pesce, Karen, Conti, Filippo, Rimmelé, Thomas, Textoris, Julien, Vedrine, Christophe, Quemeneur, Laurence, Griffiths, Andrew D., Tan, Lionel K., Venet, Fabienne, Maucort-Boulch, Delphine, Monneret, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667763/
https://www.ncbi.nlm.nih.gov/pubmed/34912347
http://dx.doi.org/10.3389/fimmu.2021.795052
Descripción
Sumario:Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis.