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Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667763/ https://www.ncbi.nlm.nih.gov/pubmed/34912347 http://dx.doi.org/10.3389/fimmu.2021.795052 |
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author | Bodinier, Maxime Peronnet, Estelle Brengel-Pesce, Karen Conti, Filippo Rimmelé, Thomas Textoris, Julien Vedrine, Christophe Quemeneur, Laurence Griffiths, Andrew D. Tan, Lionel K. Venet, Fabienne Maucort-Boulch, Delphine Monneret, Guillaume |
author_facet | Bodinier, Maxime Peronnet, Estelle Brengel-Pesce, Karen Conti, Filippo Rimmelé, Thomas Textoris, Julien Vedrine, Christophe Quemeneur, Laurence Griffiths, Andrew D. Tan, Lionel K. Venet, Fabienne Maucort-Boulch, Delphine Monneret, Guillaume |
author_sort | Bodinier, Maxime |
collection | PubMed |
description | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis. |
format | Online Article Text |
id | pubmed-8667763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86677632021-12-14 Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients Bodinier, Maxime Peronnet, Estelle Brengel-Pesce, Karen Conti, Filippo Rimmelé, Thomas Textoris, Julien Vedrine, Christophe Quemeneur, Laurence Griffiths, Andrew D. Tan, Lionel K. Venet, Fabienne Maucort-Boulch, Delphine Monneret, Guillaume Front Immunol Immunology Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8667763/ /pubmed/34912347 http://dx.doi.org/10.3389/fimmu.2021.795052 Text en Copyright © 2021 Bodinier, Peronnet, Brengel-Pesce, Conti, Rimmelé, Textoris, Vedrine, Quemeneur, Griffiths, Tan, Venet, Maucort-Boulch and Monneret https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Bodinier, Maxime Peronnet, Estelle Brengel-Pesce, Karen Conti, Filippo Rimmelé, Thomas Textoris, Julien Vedrine, Christophe Quemeneur, Laurence Griffiths, Andrew D. Tan, Lionel K. Venet, Fabienne Maucort-Boulch, Delphine Monneret, Guillaume Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title | Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title_full | Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title_fullStr | Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title_full_unstemmed | Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title_short | Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients |
title_sort | monocyte trajectories endotypes are associated with worsening in septic patients |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667763/ https://www.ncbi.nlm.nih.gov/pubmed/34912347 http://dx.doi.org/10.3389/fimmu.2021.795052 |
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