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Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR...

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Autores principales: Bodinier, Maxime, Peronnet, Estelle, Brengel-Pesce, Karen, Conti, Filippo, Rimmelé, Thomas, Textoris, Julien, Vedrine, Christophe, Quemeneur, Laurence, Griffiths, Andrew D., Tan, Lionel K., Venet, Fabienne, Maucort-Boulch, Delphine, Monneret, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667763/
https://www.ncbi.nlm.nih.gov/pubmed/34912347
http://dx.doi.org/10.3389/fimmu.2021.795052
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author Bodinier, Maxime
Peronnet, Estelle
Brengel-Pesce, Karen
Conti, Filippo
Rimmelé, Thomas
Textoris, Julien
Vedrine, Christophe
Quemeneur, Laurence
Griffiths, Andrew D.
Tan, Lionel K.
Venet, Fabienne
Maucort-Boulch, Delphine
Monneret, Guillaume
author_facet Bodinier, Maxime
Peronnet, Estelle
Brengel-Pesce, Karen
Conti, Filippo
Rimmelé, Thomas
Textoris, Julien
Vedrine, Christophe
Quemeneur, Laurence
Griffiths, Andrew D.
Tan, Lionel K.
Venet, Fabienne
Maucort-Boulch, Delphine
Monneret, Guillaume
author_sort Bodinier, Maxime
collection PubMed
description Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis.
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spelling pubmed-86677632021-12-14 Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients Bodinier, Maxime Peronnet, Estelle Brengel-Pesce, Karen Conti, Filippo Rimmelé, Thomas Textoris, Julien Vedrine, Christophe Quemeneur, Laurence Griffiths, Andrew D. Tan, Lionel K. Venet, Fabienne Maucort-Boulch, Delphine Monneret, Guillaume Front Immunol Immunology Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8667763/ /pubmed/34912347 http://dx.doi.org/10.3389/fimmu.2021.795052 Text en Copyright © 2021 Bodinier, Peronnet, Brengel-Pesce, Conti, Rimmelé, Textoris, Vedrine, Quemeneur, Griffiths, Tan, Venet, Maucort-Boulch and Monneret https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bodinier, Maxime
Peronnet, Estelle
Brengel-Pesce, Karen
Conti, Filippo
Rimmelé, Thomas
Textoris, Julien
Vedrine, Christophe
Quemeneur, Laurence
Griffiths, Andrew D.
Tan, Lionel K.
Venet, Fabienne
Maucort-Boulch, Delphine
Monneret, Guillaume
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title_full Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title_fullStr Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title_full_unstemmed Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title_short Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
title_sort monocyte trajectories endotypes are associated with worsening in septic patients
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667763/
https://www.ncbi.nlm.nih.gov/pubmed/34912347
http://dx.doi.org/10.3389/fimmu.2021.795052
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