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General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelo...

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Autores principales: Cui, Jianchen, Park, Jiho, Ju, Xianshu, Lee, Yulim, Hong, Boohwi, Ahn, Jeonghoon, Kim, Yoon Hee, Ko, Youngkwon, Yoon, Seok-Hwa, Lim, Chaeseong, Lee, Sun Yeul, Huh, Sung-Oh, Heo, Jun Young, Chung, Woosuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667765/
https://www.ncbi.nlm.nih.gov/pubmed/34912193
http://dx.doi.org/10.3389/fncel.2021.772047
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author Cui, Jianchen
Park, Jiho
Ju, Xianshu
Lee, Yulim
Hong, Boohwi
Ahn, Jeonghoon
Kim, Yoon Hee
Ko, Youngkwon
Yoon, Seok-Hwa
Lim, Chaeseong
Lee, Sun Yeul
Huh, Sung-Oh
Heo, Jun Young
Chung, Woosuk
author_facet Cui, Jianchen
Park, Jiho
Ju, Xianshu
Lee, Yulim
Hong, Boohwi
Ahn, Jeonghoon
Kim, Yoon Hee
Ko, Youngkwon
Yoon, Seok-Hwa
Lim, Chaeseong
Lee, Sun Yeul
Huh, Sung-Oh
Heo, Jun Young
Chung, Woosuk
author_sort Cui, Jianchen
collection PubMed
description Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently.
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spelling pubmed-86677652021-12-14 General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism Cui, Jianchen Park, Jiho Ju, Xianshu Lee, Yulim Hong, Boohwi Ahn, Jeonghoon Kim, Yoon Hee Ko, Youngkwon Yoon, Seok-Hwa Lim, Chaeseong Lee, Sun Yeul Huh, Sung-Oh Heo, Jun Young Chung, Woosuk Front Cell Neurosci Cellular Neuroscience Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8667765/ /pubmed/34912193 http://dx.doi.org/10.3389/fncel.2021.772047 Text en Copyright © 2021 Cui, Park, Ju, Lee, Hong, Ahn, Kim, Ko, Yoon, Lim, Lee, Huh, Heo and Chung. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Cui, Jianchen
Park, Jiho
Ju, Xianshu
Lee, Yulim
Hong, Boohwi
Ahn, Jeonghoon
Kim, Yoon Hee
Ko, Youngkwon
Yoon, Seok-Hwa
Lim, Chaeseong
Lee, Sun Yeul
Huh, Sung-Oh
Heo, Jun Young
Chung, Woosuk
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title_full General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title_fullStr General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title_full_unstemmed General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title_short General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
title_sort general anesthesia during neurodevelopment reduces autistic behavior in adult btbr mice, a murine model of autism
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667765/
https://www.ncbi.nlm.nih.gov/pubmed/34912193
http://dx.doi.org/10.3389/fncel.2021.772047
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