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Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein

We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region responsible for its anchoring in lipid droplets in the...

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Detalles Bibliográficos
Autores principales:	Ortlieb, Liliane O., Caruso, Ícaro P., Mebus-Antunes, Nathane C., Da Poian, Andrea T., Petronilho, Elaine da C., Figueroa-Villar, José Daniel, Nascimento, Claudia J., Almeida, Fabio C. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667904/ https://www.ncbi.nlm.nih.gov/pubmed/34894959 http://dx.doi.org/10.1080/14756366.2021.2004591

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