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New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy

PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the identification of novel PIN1 inhibitors a hot topi...

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Detalles Bibliográficos
Autores principales: Poli, Giulio, Di Stefano, Miriana, Estevez, Joan Arias, Minutolo, Filippo, Granchi, Carlotta, Giordano, Antonio, Parisi, Salvatore, Mauceri, Matteo, Canzonieri, Vincenzo, Macchia, Marco, Caligiuri, Isabella, Tuccinardi, Tiziano, Rizzolio, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667921/
https://www.ncbi.nlm.nih.gov/pubmed/34894990
http://dx.doi.org/10.1080/14756366.2021.1979970

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