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New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy
PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the identification of novel PIN1 inhibitors a hot topi...
Autores principales: | Poli, Giulio, Di Stefano, Miriana, Estevez, Joan Arias, Minutolo, Filippo, Granchi, Carlotta, Giordano, Antonio, Parisi, Salvatore, Mauceri, Matteo, Canzonieri, Vincenzo, Macchia, Marco, Caligiuri, Isabella, Tuccinardi, Tiziano, Rizzolio, Flavio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667921/ https://www.ncbi.nlm.nih.gov/pubmed/34894990 http://dx.doi.org/10.1080/14756366.2021.1979970 |
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