GABA(A) Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil

Fipronil (FPN) is a worldwide-used neurotoxic insecticide, targeting, and blocking GABA(A) receptors (GABA(A)Rs). Beyond its efficiency on insect GABA(A)Rs, FPN causes neurotoxic effects in humans and mammals. Here, we investigated the mode of action of FPN on mammalian α6-containing GABA(A)Rs to un...

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Detalles Bibliográficos
Autores principales: Soualah, Zineb, Taly, Antoine, Crespin, Lucille, Saulais, Ophélie, Henrion, Daniel, Legendre, Claire, Tricoire-Leignel, Hélène, Legros, Christian, Mattei, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668240/
https://www.ncbi.nlm.nih.gov/pubmed/34912189
http://dx.doi.org/10.3389/fnins.2021.768466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668240/
https://www.ncbi.nlm.nih.gov/pubmed/34912189
http://dx.doi.org/10.3389/fnins.2021.768466

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