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Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study

BACKGROUND: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and pattern...

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Autores principales: Abdelgalil Ali Ahmed, Sulafah, Adam Essa, Mohammed Elmujtba, Ahmed, Amar F, Elagib, Elnour Mohammed, Ahmed Eltahir, Noha Ibrahim, Awadallah, Huyam, Hassan, Abubakr, khair, Amna Sirag Mohammed, Ebad, Mustafa Abdalla bakhit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668256/
https://www.ncbi.nlm.nih.gov/pubmed/34916856
http://dx.doi.org/10.2147/OARRR.S335206
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author Abdelgalil Ali Ahmed, Sulafah
Adam Essa, Mohammed Elmujtba
Ahmed, Amar F
Elagib, Elnour Mohammed
Ahmed Eltahir, Noha Ibrahim
Awadallah, Huyam
Hassan, Abubakr
khair, Amna Sirag Mohammed
Ebad, Mustafa Abdalla bakhit
author_facet Abdelgalil Ali Ahmed, Sulafah
Adam Essa, Mohammed Elmujtba
Ahmed, Amar F
Elagib, Elnour Mohammed
Ahmed Eltahir, Noha Ibrahim
Awadallah, Huyam
Hassan, Abubakr
khair, Amna Sirag Mohammed
Ebad, Mustafa Abdalla bakhit
author_sort Abdelgalil Ali Ahmed, Sulafah
collection PubMed
description BACKGROUND: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and patterns of MCTD. METHODS: This is a descriptive cross-sectional hospital-based study conducted at the rheumatology clinic at Omdurman Military Hospital between February 2019 and July 2019. The study included 30 patients and data were collected using a designated questionnaire. RESULTS: The study showed that the majority of patients (96.7%) were females and only 3.3% was male. About 30% of the patients aged between 30 and 39 years were the most affected. As a first diagnosis, 10% of the patients had a MCTD fulfilling the Alarcon-Segovia criteria. The remaining 90% of the patients were diagnosed with other diseases before evolving into MCTD. The most common clinical presentation was arthralgia in 100% of the patients, 90% were symmetrically followed by myositis in 70% of the patients, arthritis in 63.3% of the patients, puffy fingers in 63.3% of the patients, and hand swelling in 60% as major musculoskeletal symptoms. Regarding the initial results in immunological profile, the most common positive autoantibodies among the patients were anti-RNP titer in 96.7% of the patients, ANA in 90%, anti-Sm in 50%, RF in 50%, anti-Ds DNA in 46.7%, and anti-Ro in 43.3%. CONCLUSION: This study showed that MCTD is more common in females, only 10% of patients presented with a fulfilling criteria of the disease at diagnosis, and the rest of the patients presented with other rheumatologic diseases before evolving into MCTD.
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spelling pubmed-86682562021-12-15 Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study Abdelgalil Ali Ahmed, Sulafah Adam Essa, Mohammed Elmujtba Ahmed, Amar F Elagib, Elnour Mohammed Ahmed Eltahir, Noha Ibrahim Awadallah, Huyam Hassan, Abubakr khair, Amna Sirag Mohammed Ebad, Mustafa Abdalla bakhit Open Access Rheumatol Original Research BACKGROUND: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and patterns of MCTD. METHODS: This is a descriptive cross-sectional hospital-based study conducted at the rheumatology clinic at Omdurman Military Hospital between February 2019 and July 2019. The study included 30 patients and data were collected using a designated questionnaire. RESULTS: The study showed that the majority of patients (96.7%) were females and only 3.3% was male. About 30% of the patients aged between 30 and 39 years were the most affected. As a first diagnosis, 10% of the patients had a MCTD fulfilling the Alarcon-Segovia criteria. The remaining 90% of the patients were diagnosed with other diseases before evolving into MCTD. The most common clinical presentation was arthralgia in 100% of the patients, 90% were symmetrically followed by myositis in 70% of the patients, arthritis in 63.3% of the patients, puffy fingers in 63.3% of the patients, and hand swelling in 60% as major musculoskeletal symptoms. Regarding the initial results in immunological profile, the most common positive autoantibodies among the patients were anti-RNP titer in 96.7% of the patients, ANA in 90%, anti-Sm in 50%, RF in 50%, anti-Ds DNA in 46.7%, and anti-Ro in 43.3%. CONCLUSION: This study showed that MCTD is more common in females, only 10% of patients presented with a fulfilling criteria of the disease at diagnosis, and the rest of the patients presented with other rheumatologic diseases before evolving into MCTD. Dove 2021-12-09 /pmc/articles/PMC8668256/ /pubmed/34916856 http://dx.doi.org/10.2147/OARRR.S335206 Text en © 2021 Abdelgalil Ali Ahmed et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Abdelgalil Ali Ahmed, Sulafah
Adam Essa, Mohammed Elmujtba
Ahmed, Amar F
Elagib, Elnour Mohammed
Ahmed Eltahir, Noha Ibrahim
Awadallah, Huyam
Hassan, Abubakr
khair, Amna Sirag Mohammed
Ebad, Mustafa Abdalla bakhit
Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title_full Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title_fullStr Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title_full_unstemmed Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title_short Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study
title_sort incidence and clinical pattern of mixed connective tissue disease in sudanese patients at omdurman military hospital: hospital-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668256/
https://www.ncbi.nlm.nih.gov/pubmed/34916856
http://dx.doi.org/10.2147/OARRR.S335206
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