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Ethnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature

Pharmacogenomic screening can identify patients with gene variants that predispose them to the development of severe toxicity from fluoropyrimidine (FP) chemotherapy. Deficiency of the critical metabolic enzyme dihydropyrimidine dehydrogenase (DPD) leads to excessive toxicity on exposure to fluoropy...

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Detalles Bibliográficos
Autores principales:	White, Cassandra, Scott, Rodney J, Paul, Christine, Ziolkowski, Andrew, Mossman, David, Ackland, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668257/ https://www.ncbi.nlm.nih.gov/pubmed/34916829 http://dx.doi.org/10.2147/PGPM.S337147

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