Cargando…

Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)

BACKGROUND: We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface D...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yan, Yang, Sen, Zhang, Yue, Zhang, Xin, Jiang, Yaping, Wang, Xixi, Zheng, Pengxiang, Chen, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668290/
https://www.ncbi.nlm.nih.gov/pubmed/34912574
http://dx.doi.org/10.1155/2021/2678706
_version_ 1784614538737352704
author Wang, Yan
Yang, Sen
Zhang, Yue
Zhang, Xin
Jiang, Yaping
Wang, Xixi
Zheng, Pengxiang
Chen, Yihui
author_facet Wang, Yan
Yang, Sen
Zhang, Yue
Zhang, Xin
Jiang, Yaping
Wang, Xixi
Zheng, Pengxiang
Chen, Yihui
author_sort Wang, Yan
collection PubMed
description BACKGROUND: We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. RESULTS: A total of 42 patients consented to complete the investigation (response rate 46.15%). There were 26 (61.90%) patients who were diagnosed with DED symptoms by OSDI, and there were 28 (66.67%) patients with DED symptoms who were diagnosed by DEQ-5 score. For the biochemical tests, the patients with DED symptoms had lower aspartate aminotransferase (AST) levels compared to those with no DED symptoms (20.86 vs. 42.14, p=0.04). Further analysis showed that a previous history of cardiac or stroke disease (p=0.02) and typical symptoms of muscle soreness (p=0.03) were significantly different among the four DED symptoms groups on the basis of OSDI scores. The contributing factors of OSDI were mainly focused on visual function and environmental triggers. CONCLUSION: The incidence of DED symptoms is higher in hospitalized patients with COVID-19. The serum AST levels, history of cardiac or stroke disease, and the typical symptoms of muscle soreness may be the main impact factors on DED symptoms. We also need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19.
format Online
Article
Text
id pubmed-8668290
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-86682902021-12-14 Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19) Wang, Yan Yang, Sen Zhang, Yue Zhang, Xin Jiang, Yaping Wang, Xixi Zheng, Pengxiang Chen, Yihui J Ophthalmol Research Article BACKGROUND: We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. RESULTS: A total of 42 patients consented to complete the investigation (response rate 46.15%). There were 26 (61.90%) patients who were diagnosed with DED symptoms by OSDI, and there were 28 (66.67%) patients with DED symptoms who were diagnosed by DEQ-5 score. For the biochemical tests, the patients with DED symptoms had lower aspartate aminotransferase (AST) levels compared to those with no DED symptoms (20.86 vs. 42.14, p=0.04). Further analysis showed that a previous history of cardiac or stroke disease (p=0.02) and typical symptoms of muscle soreness (p=0.03) were significantly different among the four DED symptoms groups on the basis of OSDI scores. The contributing factors of OSDI were mainly focused on visual function and environmental triggers. CONCLUSION: The incidence of DED symptoms is higher in hospitalized patients with COVID-19. The serum AST levels, history of cardiac or stroke disease, and the typical symptoms of muscle soreness may be the main impact factors on DED symptoms. We also need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19. Hindawi 2021-12-08 /pmc/articles/PMC8668290/ /pubmed/34912574 http://dx.doi.org/10.1155/2021/2678706 Text en Copyright © 2021 Yan Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yan
Yang, Sen
Zhang, Yue
Zhang, Xin
Jiang, Yaping
Wang, Xixi
Zheng, Pengxiang
Chen, Yihui
Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title_full Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title_fullStr Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title_full_unstemmed Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title_short Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)
title_sort symptoms of dry eye disease in hospitalized patients with coronavirus disease 2019 (covid-19)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668290/
https://www.ncbi.nlm.nih.gov/pubmed/34912574
http://dx.doi.org/10.1155/2021/2678706
work_keys_str_mv AT wangyan symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT yangsen symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT zhangyue symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT zhangxin symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT jiangyaping symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT wangxixi symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT zhengpengxiang symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19
AT chenyihui symptomsofdryeyediseaseinhospitalizedpatientswithcoronavirusdisease2019covid19