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Research on Network Model of Dentate Gyrus Based on Bionics

As an important part of the brain, the dentate gyrus has an irreplaceable effect in the process of memory generation. Therefore, the study of the dentate gyrus model has important significance in the study of brain function. This paper, combined with the real anatomical structure of the dentate gyru...

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Detalles Bibliográficos
Autores principales: Zhang, Jin, Wei, Xiaoping, Zhang, Shiwen, Niu, Xin, Li, Guang, Tian, Tiantian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668295/
https://www.ncbi.nlm.nih.gov/pubmed/34912532
http://dx.doi.org/10.1155/2021/4609741
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author Zhang, Jin
Wei, Xiaoping
Zhang, Shiwen
Niu, Xin
Li, Guang
Tian, Tiantian
author_facet Zhang, Jin
Wei, Xiaoping
Zhang, Shiwen
Niu, Xin
Li, Guang
Tian, Tiantian
author_sort Zhang, Jin
collection PubMed
description As an important part of the brain, the dentate gyrus has an irreplaceable effect in the process of memory generation. Therefore, the study of the dentate gyrus model has important significance in the study of brain function. This paper, combined with the real anatomical structure of the dentate gyrus, is based on the existing calculation model for studying the pathological state of the dentate gyrus, a network model of dentate gyrus based on bionics. Then, a simulation experiment on the normal dentate gyrus model is performed on the NEURON platform, the output of each neuron in the model is observed, and a conclusion that the improved model can respond to stimuli, generate action potentials, and transmit them along with the neural network is made. At the same time, the output results are compared with the existing pathological models, and the characteristics of the stimulus response between neurons in the dentate gyrus under normal physiological conditions are obtained. Finally, according to the semiquantitative classification definition and quantitative classification definition of the small-world network, the model is analyzed, and it is concluded that the improved dentate gyrus network model has small-world characteristics. Therefore, the neurons in the improved dentate gyrus model are tightly connected and can simulate the real dentate gyrus to a certain extent.
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spelling pubmed-86682952021-12-14 Research on Network Model of Dentate Gyrus Based on Bionics Zhang, Jin Wei, Xiaoping Zhang, Shiwen Niu, Xin Li, Guang Tian, Tiantian J Healthc Eng Research Article As an important part of the brain, the dentate gyrus has an irreplaceable effect in the process of memory generation. Therefore, the study of the dentate gyrus model has important significance in the study of brain function. This paper, combined with the real anatomical structure of the dentate gyrus, is based on the existing calculation model for studying the pathological state of the dentate gyrus, a network model of dentate gyrus based on bionics. Then, a simulation experiment on the normal dentate gyrus model is performed on the NEURON platform, the output of each neuron in the model is observed, and a conclusion that the improved model can respond to stimuli, generate action potentials, and transmit them along with the neural network is made. At the same time, the output results are compared with the existing pathological models, and the characteristics of the stimulus response between neurons in the dentate gyrus under normal physiological conditions are obtained. Finally, according to the semiquantitative classification definition and quantitative classification definition of the small-world network, the model is analyzed, and it is concluded that the improved dentate gyrus network model has small-world characteristics. Therefore, the neurons in the improved dentate gyrus model are tightly connected and can simulate the real dentate gyrus to a certain extent. Hindawi 2021-12-06 /pmc/articles/PMC8668295/ /pubmed/34912532 http://dx.doi.org/10.1155/2021/4609741 Text en Copyright © 2021 Jin Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Jin
Wei, Xiaoping
Zhang, Shiwen
Niu, Xin
Li, Guang
Tian, Tiantian
Research on Network Model of Dentate Gyrus Based on Bionics
title Research on Network Model of Dentate Gyrus Based on Bionics
title_full Research on Network Model of Dentate Gyrus Based on Bionics
title_fullStr Research on Network Model of Dentate Gyrus Based on Bionics
title_full_unstemmed Research on Network Model of Dentate Gyrus Based on Bionics
title_short Research on Network Model of Dentate Gyrus Based on Bionics
title_sort research on network model of dentate gyrus based on bionics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668295/
https://www.ncbi.nlm.nih.gov/pubmed/34912532
http://dx.doi.org/10.1155/2021/4609741
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