Bevacizumab Increases Endothelin-1 Production via Forkhead Box Protein O1 in Human Glomerular Microvascular Endothelial Cells In Vitro

Molecular mechanisms underlying the nephrotoxicity associated with bevacizumab are unclear. Endothelin-1 (ET-1) is involved in podocyte injury and proteinuria, and its level increases in most cases of kidney disorders. Forkhead box protein O1 (FoxO1), a transcription factor, is a major determinant o...

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Detalles Bibliográficos
Autores principales: Nihei, Satoru, Asaka, Junichi, Takahashi, Hiroaki, Kudo, Kenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668358/
https://www.ncbi.nlm.nih.gov/pubmed/34912580
http://dx.doi.org/10.1155/2021/8381115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668358/
https://www.ncbi.nlm.nih.gov/pubmed/34912580
http://dx.doi.org/10.1155/2021/8381115

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