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Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway

Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading to ligamentum flavum hypertrophy (LFH). However, the mechanism of mechanical stress in the formation of collagen remains unclear. Therefore, we investigated the relationship between mechanical...

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Detalles Bibliográficos
Autores principales:	Yan, Bin, Zeng, Canjun, Chen, Yuhui, Huang, Minjun, Yao, Na, Zhang, Jie, Yan, Bo, Tang, Jiajun, Wang, Liang, Zhang, Zhongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668368/ https://www.ncbi.nlm.nih.gov/pubmed/34912459 http://dx.doi.org/10.1155/2021/5553676

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