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An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition

In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the risk of HIV-1 acquisition. A follow-on trial, HVTN702, of a similar vaccine candidate found no efficacy in South Africa, where the predominant population is polymorphic for only...

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Detalles Bibliográficos
Autores principales:	Ebonwu, Joy, Lassaunière, Ria, Paximadis, Maria, Goosen, Mark, Strehlau, Renate, Gray, Glenda E., Kuhn, Louise, Tiemessen, Caroline T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668943/ https://www.ncbi.nlm.nih.gov/pubmed/34917081 http://dx.doi.org/10.3389/fimmu.2021.760571

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