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The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study

Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its com...

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Autores principales: Zhang, Min, Chen, Jing, Yin, Zhiqun, Wang, Lanbing, Peng, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668963/
https://www.ncbi.nlm.nih.gov/pubmed/34903730
http://dx.doi.org/10.1038/s41398-021-01759-z
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author Zhang, Min
Chen, Jing
Yin, Zhiqun
Wang, Lanbing
Peng, Lihua
author_facet Zhang, Min
Chen, Jing
Yin, Zhiqun
Wang, Lanbing
Peng, Lihua
author_sort Zhang, Min
collection PubMed
description Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091–1.374, p = 5.58 × 10(−4)), waist circumference (OR: 1.083, 95% CI: 1.027–1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016–1.039, p = 1.34 × 10(−6)) and triglycerides (OR: 1.111, 95% CI: 1.060–1.163, p = 9.35 × 10(−6)) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885–0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986–1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components.
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spelling pubmed-86689632021-12-28 The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study Zhang, Min Chen, Jing Yin, Zhiqun Wang, Lanbing Peng, Lihua Transl Psychiatry Article Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091–1.374, p = 5.58 × 10(−4)), waist circumference (OR: 1.083, 95% CI: 1.027–1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016–1.039, p = 1.34 × 10(−6)) and triglycerides (OR: 1.111, 95% CI: 1.060–1.163, p = 9.35 × 10(−6)) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885–0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986–1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components. Nature Publishing Group UK 2021-12-13 /pmc/articles/PMC8668963/ /pubmed/34903730 http://dx.doi.org/10.1038/s41398-021-01759-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Min
Chen, Jing
Yin, Zhiqun
Wang, Lanbing
Peng, Lihua
The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title_full The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title_fullStr The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title_full_unstemmed The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title_short The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
title_sort association between depression and metabolic syndrome and its components: a bidirectional two-sample mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668963/
https://www.ncbi.nlm.nih.gov/pubmed/34903730
http://dx.doi.org/10.1038/s41398-021-01759-z
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