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The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study
Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its com...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668963/ https://www.ncbi.nlm.nih.gov/pubmed/34903730 http://dx.doi.org/10.1038/s41398-021-01759-z |
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author | Zhang, Min Chen, Jing Yin, Zhiqun Wang, Lanbing Peng, Lihua |
author_facet | Zhang, Min Chen, Jing Yin, Zhiqun Wang, Lanbing Peng, Lihua |
author_sort | Zhang, Min |
collection | PubMed |
description | Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091–1.374, p = 5.58 × 10(−4)), waist circumference (OR: 1.083, 95% CI: 1.027–1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016–1.039, p = 1.34 × 10(−6)) and triglycerides (OR: 1.111, 95% CI: 1.060–1.163, p = 9.35 × 10(−6)) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885–0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986–1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components. |
format | Online Article Text |
id | pubmed-8668963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86689632021-12-28 The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study Zhang, Min Chen, Jing Yin, Zhiqun Wang, Lanbing Peng, Lihua Transl Psychiatry Article Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091–1.374, p = 5.58 × 10(−4)), waist circumference (OR: 1.083, 95% CI: 1.027–1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016–1.039, p = 1.34 × 10(−6)) and triglycerides (OR: 1.111, 95% CI: 1.060–1.163, p = 9.35 × 10(−6)) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885–0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986–1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components. Nature Publishing Group UK 2021-12-13 /pmc/articles/PMC8668963/ /pubmed/34903730 http://dx.doi.org/10.1038/s41398-021-01759-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Min Chen, Jing Yin, Zhiqun Wang, Lanbing Peng, Lihua The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title | The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title_full | The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title_fullStr | The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title_full_unstemmed | The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title_short | The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study |
title_sort | association between depression and metabolic syndrome and its components: a bidirectional two-sample mendelian randomization study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668963/ https://www.ncbi.nlm.nih.gov/pubmed/34903730 http://dx.doi.org/10.1038/s41398-021-01759-z |
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