Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia

The impact of clonal heterogeneity on disease behavior or drug response in acute myeloid leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features of clonality associated with clinical features and drug sensitivities. High variant allele frequency for 7 mutations (in...

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Detalles Bibliográficos
Autores principales: Benard, Brooks A., Leak, Logan B., Azizi, Armon, Thomas, Daniel, Gentles, Andrew J., Majeti, Ravindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669028/
https://www.ncbi.nlm.nih.gov/pubmed/34903734
http://dx.doi.org/10.1038/s41467-021-27472-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669028/
https://www.ncbi.nlm.nih.gov/pubmed/34903734
http://dx.doi.org/10.1038/s41467-021-27472-5

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