Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

BACKGROUND: We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model perf...

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Detalles Bibliográficos
Autores principales: Karunamuni, Roshan A., Huynh-Le, Minh-Phuong, Fan, Chun C., Thompson, Wesley, Lui, Asona, Martinez, Maria Elena, Rose, Brent S., Mahal, Brandon, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Lophatananon, Artitaya, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Ian M., Blot, William J., Zheng, Wei, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Park, Jong Y., Lin, Hui-Yi, Taylor, Jack A., Bensen, Jeannette T., Mohler, James L., Fontham, Elizabeth T.H., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Romana, Marc, Leach, Robin J., John, Esther M., Fowke, Jay H., Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Cullen, Jennifer, Petrovics, Gyorgy, Parent, Marie-Élise, Hu, Jennifer J., Sanderson, Maureen, Mills, Ian G., Andreassen, Ole A., Dale, Anders M., Seibert, Tyler M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669040/
https://www.ncbi.nlm.nih.gov/pubmed/34127801
http://dx.doi.org/10.1038/s41391-021-00403-7

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