Cargando…

Bacteria Are New Targets for Inhibitors of Human Farnesyltransferase

Farnesyltransferase inhibitors (FTIs) are focus for the treatment of several diseases, particularly in the field of cancer therapy. Their potential, however, goes even further, as a number of studies have evaluated FTIs for the treatment of infectious diseases such as malaria, African sleeping sickn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weber, Lea, Hagemann, Anna, Kaltenhäuser, Jila, Besser, Manuela, Rockenfeller, Patrick, Ehrhardt, Anja, Stuermer, Ewa, Bachmann, Hagen Sjard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669142/ https://www.ncbi.nlm.nih.gov/pubmed/34917041 http://dx.doi.org/10.3389/fmicb.2021.628283

Ejemplares similares

Effect of farnesyltransferase inhibitors on SARS-CoV-2
por: Weber, Lea, et al.
Publicado: (2023)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
por: Hagemann, Anna, et al.
Publicado: (2022)

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
por: Probst, Alexandra, et al.
Publicado: (2019)

New targets for therapy in breast cancer: Farnesyltransferase inhibitors
por: Head, Julia, et al.
Publicado: (2004)

Antimicrobial Hypochlorous Wound Irrigation Solutions Demonstrate Lower Anti-biofilm Efficacy Against Bacterial Biofilm in a Complex in-vitro Human Plasma Biofilm Model (hpBIOM) Than Common Wound Antimicrobials
por: Rembe, Julian-Dario, et al.
Publicado: (2020)

New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitors
por: Gonçalves, A Cristina, et al.
Publicado: (2010)

Effect of farnesyltransferase inhibitor on the function of mitochondria of Plasmodium falciparum
por: Ha, Young Ran, et al.
Publicado: (2012)

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
por: Dai, Xiaohan, et al.
Publicado: (2020)

The Farnesyltransferase β-Subunit Ram1 Regulates Sporisorium scitamineum Mating, Pathogenicity and Cell Wall Integrity
por: Sun, Shuquan, et al.
Publicado: (2019)

Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties
por: Hagemann, Anna, et al.
Publicado: (2022)

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
por: Yang, Shao H., et al.
Publicado: (2010)

Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum
por: Ha, Young Ran, et al.
Publicado: (2015)

Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA
por: Xu, Tao, et al.
Publicado: (2016)

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor
por: DeGeorge, Katharine C, et al.
Publicado: (2008)

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase
por: Zubaș, Andreea, et al.
Publicado: (2023)

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida
por: Qiao, Jianjun, et al.
Publicado: (2013)

Cooperative Genomic Lesions in HRAS-Mutant Cancers Predict Resistance to Farnesyltransferase Inhibitors
por: Nigam, Aradhya, et al.
Publicado: (2023)

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells
por: Ma, Yufang, et al.
Publicado: (2017)

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
por: Gajewski, Thomas F, et al.
Publicado: (2012)

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors
por: Holland, Andrew J., et al.
Publicado: (2015)

Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques
por: Al-Balas, Qosay A., et al.
Publicado: (2013)

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
por: Cuddy, Leah K., et al.
Publicado: (2022)

Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice
por: Tanaka, Tomokazu, et al.
Publicado: (2018)

Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells
por: Arnold, Rouven, et al.
Publicado: (2021)

Engineering Protein Farnesyltransferase for Enzymatic Protein Labeling Applications
por: Dozier, Jonathan K., et al.
Publicado: (2014)

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts
por: Gabriel, Diana, et al.
Publicado: (2017)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
por: Ha, Nguyen Thi, et al.
Publicado: (2020)

2D-QSAR study of some 2,5-diaminobenzophenone farnesyltransferase inhibitors by different chemometric methods
por: Ghanbarzadeh, Saeed, et al.
Publicado: (2015)

In Vitro Apoptotic Effects of Farnesyltransferase blockade in Acute Myeloid Leukemia Cells
por: Giudice, V, et al.
Publicado: (2016)

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans
por: Carr, David, et al.
Publicado: (2016)

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase
por: Schey, Garrett L., et al.
Publicado: (2021)

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
por: Mehta, Ishita S, et al.
Publicado: (2011)

Enhanced Antiproliferative and Apoptotic Response of HT-29 Adenocarcinoma Cells to Combination of Photoactivated Hypericin and Farnesyltransferase Inhibitor Manumycin A
por: Sačková, Veronika, et al.
Publicado: (2011)

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression
por: Yamada, Kohei, et al.
Publicado: (2023)

Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy
por: Zhang, Yi, et al.
Publicado: (2022)

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts
por: Bikkul, Mehmet U., et al.
Publicado: (2018)

Protective effects of farnesyltransferase inhibitor on sepsis-induced morphological aberrations of mitochondria in muscle and increased circulating mitochondrial DNA levels in mice
por: Tsuji, Daisuke, et al.
Publicado: (2021)

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase
por: Stevens, Emily, et al.
Publicado: (2017)

In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against Naegleria fowleri
por: Hahn, Hye Jee, et al.
Publicado: (2020)

Association of a Common Oxytocin Receptor Gene Polymorphism with Self-Reported ‘Empathic Concern’ in a Large Population of Healthy Volunteers
por: Huetter, Franz Korbinian, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r2fie1eurjik77dadbtlds85g2