Cargando…
Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota
Antibiotic inefficacy in treating bacterial infections is largely studied in the context of developing resistance mechanisms. However, little attention has been paid to combined diseases mechanisms, interspecies pathogenesis and the resulting impact on antimicrobial treatment. This review will consi...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669234/ https://www.ncbi.nlm.nih.gov/pubmed/34905113 http://dx.doi.org/10.1007/s00284-021-02718-z |
_version_ | 1784614740527415296 |
---|---|
author | Bajinka, Ousman Qi, Mingming Barrow, Amadou Touray, Abdoulie O. Yang, Lulu Tan, Yurong |
author_facet | Bajinka, Ousman Qi, Mingming Barrow, Amadou Touray, Abdoulie O. Yang, Lulu Tan, Yurong |
author_sort | Bajinka, Ousman |
collection | PubMed |
description | Antibiotic inefficacy in treating bacterial infections is largely studied in the context of developing resistance mechanisms. However, little attention has been paid to combined diseases mechanisms, interspecies pathogenesis and the resulting impact on antimicrobial treatment. This review will consider the co-infections of Salmonella and Schistosoma mansoni. It summarises the protective mechanisms that the pathophysiology of the two infections confer, which leads to an antibiotic protection phenomenon. This review will elucidate the functional characteristics of the gut microbiota in the context of these co-infections, the pathogenicity of these infections in infected mice, and the efficacy of the antibiotics used in treatment of these co-infections over time. Salmonella-Schistosoma interactions and the mechanism for antibiotic protection are not well established. However, antimicrobial drug inefficacy is an existing phenomenon in these co-infections. The treatment of schistosomiasis to ensure the efficacy of antibiotic therapy for bacterial infections should be considered in co-infected patients. GRAPHICAL ABSTRACT: [Image: see text] Co-infections of Salmonella and Schistosoma mansoni confers the protective mechanisms that give ineffetive treatment of salmonella. The functional characteristics of the gut microbiota in the context of these co-infections influence the pathogenicity of the both pathogens thereby drecreasing immunity and brings changes in gut metabolism. |
format | Online Article Text |
id | pubmed-8669234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-86692342021-12-14 Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota Bajinka, Ousman Qi, Mingming Barrow, Amadou Touray, Abdoulie O. Yang, Lulu Tan, Yurong Curr Microbiol Review Article Antibiotic inefficacy in treating bacterial infections is largely studied in the context of developing resistance mechanisms. However, little attention has been paid to combined diseases mechanisms, interspecies pathogenesis and the resulting impact on antimicrobial treatment. This review will consider the co-infections of Salmonella and Schistosoma mansoni. It summarises the protective mechanisms that the pathophysiology of the two infections confer, which leads to an antibiotic protection phenomenon. This review will elucidate the functional characteristics of the gut microbiota in the context of these co-infections, the pathogenicity of these infections in infected mice, and the efficacy of the antibiotics used in treatment of these co-infections over time. Salmonella-Schistosoma interactions and the mechanism for antibiotic protection are not well established. However, antimicrobial drug inefficacy is an existing phenomenon in these co-infections. The treatment of schistosomiasis to ensure the efficacy of antibiotic therapy for bacterial infections should be considered in co-infected patients. GRAPHICAL ABSTRACT: [Image: see text] Co-infections of Salmonella and Schistosoma mansoni confers the protective mechanisms that give ineffetive treatment of salmonella. The functional characteristics of the gut microbiota in the context of these co-infections influence the pathogenicity of the both pathogens thereby drecreasing immunity and brings changes in gut metabolism. Springer US 2021-12-14 2022 /pmc/articles/PMC8669234/ /pubmed/34905113 http://dx.doi.org/10.1007/s00284-021-02718-z Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Bajinka, Ousman Qi, Mingming Barrow, Amadou Touray, Abdoulie O. Yang, Lulu Tan, Yurong Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title | Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title_full | Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title_fullStr | Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title_full_unstemmed | Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title_short | Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota |
title_sort | pathogenicity of salmonella during schistosoma-salmonella co-infections and the importance of the gut microbiota |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669234/ https://www.ncbi.nlm.nih.gov/pubmed/34905113 http://dx.doi.org/10.1007/s00284-021-02718-z |
work_keys_str_mv | AT bajinkaousman pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota AT qimingming pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota AT barrowamadou pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota AT tourayabdoulieo pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota AT yanglulu pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota AT tanyurong pathogenicityofsalmonelladuringschistosomasalmonellacoinfectionsandtheimportanceofthegutmicrobiota |