Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction

BACKGROUND: Acute myocardial infarction (AMI)-induced excessive myocardial fibrosis exaggerates cardiac dysfunction. However, serum Wnt2 or Wnt4 level in AMI patients, and the roles in cardiac fibrosis are largely unkown. METHODS: AMI and non-AMI patients were enrolled to examine serum Wnt2 and Wnt4...

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Detalles Bibliográficos
Autores principales: Yin, Chao, Ye, Zhishuai, Wu, Jian, Huang, Chenxing, Pan, Le, Ding, Huaiyu, Zhong, Lei, Guo, Lei, Zou, Yan, Wang, Xiang, Wang, Ying, Gao, Pan, Jin, Xuejuan, Yan, Xiaoxiang, Zou, Yunzeng, Huang, Rongchong, Gong, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669316/
https://www.ncbi.nlm.nih.gov/pubmed/34911029
http://dx.doi.org/10.1016/j.ebiom.2021.103745

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