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Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond

Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In th...

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Autores principales: Zhang, Shuo-Qi, Xiao, Jun, Chen, Man, Zhou, Luo-Qi, Shang, Ke, Qin, Chuan, Tian, Dai-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669352/
https://www.ncbi.nlm.nih.gov/pubmed/34916911
http://dx.doi.org/10.3389/fncel.2021.781098
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author Zhang, Shuo-Qi
Xiao, Jun
Chen, Man
Zhou, Luo-Qi
Shang, Ke
Qin, Chuan
Tian, Dai-Shi
author_facet Zhang, Shuo-Qi
Xiao, Jun
Chen, Man
Zhou, Luo-Qi
Shang, Ke
Qin, Chuan
Tian, Dai-Shi
author_sort Zhang, Shuo-Qi
collection PubMed
description Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway.
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spelling pubmed-86693522021-12-15 Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond Zhang, Shuo-Qi Xiao, Jun Chen, Man Zhou, Luo-Qi Shang, Ke Qin, Chuan Tian, Dai-Shi Front Cell Neurosci Neuroscience Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669352/ /pubmed/34916911 http://dx.doi.org/10.3389/fncel.2021.781098 Text en Copyright © 2021 Zhang, Xiao, Chen, Zhou, Shang, Qin and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Shuo-Qi
Xiao, Jun
Chen, Man
Zhou, Luo-Qi
Shang, Ke
Qin, Chuan
Tian, Dai-Shi
Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_full Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_fullStr Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_full_unstemmed Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_short Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_sort sphingosine-1-phosphate signaling in ischemic stroke: from bench to bedside and beyond
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669352/
https://www.ncbi.nlm.nih.gov/pubmed/34916911
http://dx.doi.org/10.3389/fncel.2021.781098
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