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Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669352/ https://www.ncbi.nlm.nih.gov/pubmed/34916911 http://dx.doi.org/10.3389/fncel.2021.781098 |
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author | Zhang, Shuo-Qi Xiao, Jun Chen, Man Zhou, Luo-Qi Shang, Ke Qin, Chuan Tian, Dai-Shi |
author_facet | Zhang, Shuo-Qi Xiao, Jun Chen, Man Zhou, Luo-Qi Shang, Ke Qin, Chuan Tian, Dai-Shi |
author_sort | Zhang, Shuo-Qi |
collection | PubMed |
description | Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway. |
format | Online Article Text |
id | pubmed-8669352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86693522021-12-15 Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond Zhang, Shuo-Qi Xiao, Jun Chen, Man Zhou, Luo-Qi Shang, Ke Qin, Chuan Tian, Dai-Shi Front Cell Neurosci Neuroscience Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669352/ /pubmed/34916911 http://dx.doi.org/10.3389/fncel.2021.781098 Text en Copyright © 2021 Zhang, Xiao, Chen, Zhou, Shang, Qin and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Shuo-Qi Xiao, Jun Chen, Man Zhou, Luo-Qi Shang, Ke Qin, Chuan Tian, Dai-Shi Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title_full | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title_fullStr | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title_full_unstemmed | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title_short | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
title_sort | sphingosine-1-phosphate signaling in ischemic stroke: from bench to bedside and beyond |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669352/ https://www.ncbi.nlm.nih.gov/pubmed/34916911 http://dx.doi.org/10.3389/fncel.2021.781098 |
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