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Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669475/ https://www.ncbi.nlm.nih.gov/pubmed/34917629 http://dx.doi.org/10.3389/fmed.2021.738850 |
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author | Buda, Piotr Friedman-Gruszczyńska, Joanna Książyk, Janusz |
author_facet | Buda, Piotr Friedman-Gruszczyńska, Joanna Książyk, Janusz |
author_sort | Buda, Piotr |
collection | PubMed |
description | Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD. |
format | Online Article Text |
id | pubmed-8669475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86694752021-12-15 Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives Buda, Piotr Friedman-Gruszczyńska, Joanna Książyk, Janusz Front Med (Lausanne) Medicine Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669475/ /pubmed/34917629 http://dx.doi.org/10.3389/fmed.2021.738850 Text en Copyright © 2021 Buda, Friedman-Gruszczyńska and Książyk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Buda, Piotr Friedman-Gruszczyńska, Joanna Książyk, Janusz Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title | Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title_full | Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title_fullStr | Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title_full_unstemmed | Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title_short | Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives |
title_sort | anti-inflammatory treatment of kawasaki disease: comparison of current guidelines and perspectives |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669475/ https://www.ncbi.nlm.nih.gov/pubmed/34917629 http://dx.doi.org/10.3389/fmed.2021.738850 |
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