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Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives

Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study a...

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Autores principales: Buda, Piotr, Friedman-Gruszczyńska, Joanna, Książyk, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669475/
https://www.ncbi.nlm.nih.gov/pubmed/34917629
http://dx.doi.org/10.3389/fmed.2021.738850
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author Buda, Piotr
Friedman-Gruszczyńska, Joanna
Książyk, Janusz
author_facet Buda, Piotr
Friedman-Gruszczyńska, Joanna
Książyk, Janusz
author_sort Buda, Piotr
collection PubMed
description Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD.
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spelling pubmed-86694752021-12-15 Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives Buda, Piotr Friedman-Gruszczyńska, Joanna Książyk, Janusz Front Med (Lausanne) Medicine Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased risk of coronary heart disease and is the most common cause of acquired heart disease in childhood. The incidence of KD is increasing worldwide. There are numerous international treatment guidelines. Our study aims to perform the first one so far comparison of them. While the gold standard therapy remains still the same (intravenous immunoglobulins and aspirin), there is currently a lack of evidence for choosing optimal treatment for high-risk patients and refractory KD. In this review, we also discuss the treatment of complications of KD and Kawasaki-like phenotypes, present an anti-inflammatory treatment in the light of new scientific data, and present novel potential therapeutic targets for KD. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669475/ /pubmed/34917629 http://dx.doi.org/10.3389/fmed.2021.738850 Text en Copyright © 2021 Buda, Friedman-Gruszczyńska and Książyk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Buda, Piotr
Friedman-Gruszczyńska, Joanna
Książyk, Janusz
Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_full Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_fullStr Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_full_unstemmed Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_short Anti-inflammatory Treatment of Kawasaki Disease: Comparison of Current Guidelines and Perspectives
title_sort anti-inflammatory treatment of kawasaki disease: comparison of current guidelines and perspectives
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669475/
https://www.ncbi.nlm.nih.gov/pubmed/34917629
http://dx.doi.org/10.3389/fmed.2021.738850
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