The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy

A recent study by Zheng et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonst...

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Detalles Bibliográficos
Autores principales: Platta, Harald W., Erdmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669516/
https://www.ncbi.nlm.nih.gov/pubmed/34889952
http://dx.doi.org/10.1083/jcb.202111008
Descripción
Sumario:A recent study by Zheng et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonstrate that the Torin1-dependent induction of pexophagy is executed by the MARCH5-catalyzed ubiquitination of the peroxisomal membrane protein PMP70.

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