The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy

A recent study by Zheng et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonst...

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Detalles Bibliográficos
Autores principales: Platta, Harald W., Erdmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669516/
https://www.ncbi.nlm.nih.gov/pubmed/34889952
http://dx.doi.org/10.1083/jcb.202111008
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author Platta, Harald W.
Erdmann, Ralf
author_facet Platta, Harald W.
Erdmann, Ralf
author_sort Platta, Harald W.
collection PubMed
description A recent study by Zheng et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonstrate that the Torin1-dependent induction of pexophagy is executed by the MARCH5-catalyzed ubiquitination of the peroxisomal membrane protein PMP70.
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spelling pubmed-86695162022-07-03 The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy Platta, Harald W. Erdmann, Ralf J Cell Biol Spotlight A recent study by Zheng et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103156) identifies the ubiquitin-protein ligase (E3) MARCH5 as a dual-organelle localized protein that not only targets to mitochondria but also to peroxisomes in a PEX19-mediated manner. Moreover, the authors demonstrate that the Torin1-dependent induction of pexophagy is executed by the MARCH5-catalyzed ubiquitination of the peroxisomal membrane protein PMP70. Rockefeller University Press 2021-12-10 /pmc/articles/PMC8669516/ /pubmed/34889952 http://dx.doi.org/10.1083/jcb.202111008 Text en © 2021 Platta and Erdmann https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Platta, Harald W.
Erdmann, Ralf
The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title_full The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title_fullStr The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title_full_unstemmed The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title_short The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
title_sort ides of march5: the e3 ligase essential for peroxisome degradation by pexophagy
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669516/
https://www.ncbi.nlm.nih.gov/pubmed/34889952
http://dx.doi.org/10.1083/jcb.202111008
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