P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance

B cell self-tolerance is maintained through multiple checkpoints, including restraints on intracellular signaling and cell trafficking. P2RY8 is a receptor with established roles in germinal center (GC) B cell migration inhibition and growth regulation. Somatic P2RY8 variants are common in GC-derive...

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Detalles Bibliográficos
Autores principales: He, Yuke, Gallman, Antonia E., Xie, Chengmei, Shen, Qian, Ma, Jianyang, Wolfreys, Finn D., Sandy, Moriah, Arsov, Todor, Wu, Xiaoqian, Qin, Yuting, Zhang, Pingjing, Jiang, Simon, Stanley, Maurice, Wu, Philip, Tan, Jingjing, Ding, Huihua, Xue, Haiyan, Chen, Wei, Xu, Jinping, Criswell, Lindsey A., Nititham, Joanne, Adamski, Marcin, Kitching, A. Richard, Cook, Matthew C., Cao, Lanfang, Shen, Nan, Cyster, Jason G., Vinuesa, Carola G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669517/
https://www.ncbi.nlm.nih.gov/pubmed/34889940
http://dx.doi.org/10.1084/jem.20211004

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