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Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vacci...

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Autores principales: Barasona, Jose A., Cadenas-Fernández, Estefanía, Kosowska, Aleksandra, Barroso-Arévalo, Sandra, Rivera, Belén, Sánchez, Rocío, Porras, Néstor, Gallardo, Carmina, Sánchez-Vizcaíno, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669561/
https://www.ncbi.nlm.nih.gov/pubmed/34917082
http://dx.doi.org/10.3389/fimmu.2021.761753
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author Barasona, Jose A.
Cadenas-Fernández, Estefanía
Kosowska, Aleksandra
Barroso-Arévalo, Sandra
Rivera, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno, Jose M.
author_facet Barasona, Jose A.
Cadenas-Fernández, Estefanía
Kosowska, Aleksandra
Barroso-Arévalo, Sandra
Rivera, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno, Jose M.
author_sort Barasona, Jose A.
collection PubMed
description African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.
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spelling pubmed-86695612021-12-15 Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses Barasona, Jose A. Cadenas-Fernández, Estefanía Kosowska, Aleksandra Barroso-Arévalo, Sandra Rivera, Belén Sánchez, Rocío Porras, Néstor Gallardo, Carmina Sánchez-Vizcaíno, Jose M. Front Immunol Immunology African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669561/ /pubmed/34917082 http://dx.doi.org/10.3389/fimmu.2021.761753 Text en Copyright © 2021 Barasona, Cadenas-Fernández, Kosowska, Barroso-Arévalo, Rivera, Sánchez, Porras, Gallardo and Sánchez-Vizcaíno https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Barasona, Jose A.
Cadenas-Fernández, Estefanía
Kosowska, Aleksandra
Barroso-Arévalo, Sandra
Rivera, Belén
Sánchez, Rocío
Porras, Néstor
Gallardo, Carmina
Sánchez-Vizcaíno, Jose M.
Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_fullStr Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full_unstemmed Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_short Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_sort safety of african swine fever vaccine candidate lv17/wb/rie1 in wild boar: overdose and repeated doses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669561/
https://www.ncbi.nlm.nih.gov/pubmed/34917082
http://dx.doi.org/10.3389/fimmu.2021.761753
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