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Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain...

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Autores principales: Liu, Chao, Tang, Bin, Gao, Can, Deng, Jianjun, Shen, Min, Li, Chaolin, Fu, Zekun, Gao, Zhan, Jiang, Qi, Shi, Hao, He, Miao, Jiang, Huaiwu, Jia, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669593/
https://www.ncbi.nlm.nih.gov/pubmed/34917639
http://dx.doi.org/10.3389/fmed.2021.783646
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author Liu, Chao
Tang, Bin
Gao, Can
Deng, Jianjun
Shen, Min
Li, Chaolin
Fu, Zekun
Gao, Zhan
Jiang, Qi
Shi, Hao
He, Miao
Jiang, Huaiwu
Jia, Xu
author_facet Liu, Chao
Tang, Bin
Gao, Can
Deng, Jianjun
Shen, Min
Li, Chaolin
Fu, Zekun
Gao, Zhan
Jiang, Qi
Shi, Hao
He, Miao
Jiang, Huaiwu
Jia, Xu
author_sort Liu, Chao
collection PubMed
description The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain.
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spelling pubmed-86695932021-12-15 Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China Liu, Chao Tang, Bin Gao, Can Deng, Jianjun Shen, Min Li, Chaolin Fu, Zekun Gao, Zhan Jiang, Qi Shi, Hao He, Miao Jiang, Huaiwu Jia, Xu Front Med (Lausanne) Medicine The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669593/ /pubmed/34917639 http://dx.doi.org/10.3389/fmed.2021.783646 Text en Copyright © 2021 Liu, Tang, Gao, Deng, Shen, Li, Fu, Gao, Jiang, Shi, He, Jiang and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Liu, Chao
Tang, Bin
Gao, Can
Deng, Jianjun
Shen, Min
Li, Chaolin
Fu, Zekun
Gao, Zhan
Jiang, Qi
Shi, Hao
He, Miao
Jiang, Huaiwu
Jia, Xu
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title_full Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title_fullStr Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title_full_unstemmed Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title_short Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
title_sort case report: genomic characteristics of the first known case of sars-cov-2 imported from spain to sichuan, china
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669593/
https://www.ncbi.nlm.nih.gov/pubmed/34917639
http://dx.doi.org/10.3389/fmed.2021.783646
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