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Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669593/ https://www.ncbi.nlm.nih.gov/pubmed/34917639 http://dx.doi.org/10.3389/fmed.2021.783646 |
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author | Liu, Chao Tang, Bin Gao, Can Deng, Jianjun Shen, Min Li, Chaolin Fu, Zekun Gao, Zhan Jiang, Qi Shi, Hao He, Miao Jiang, Huaiwu Jia, Xu |
author_facet | Liu, Chao Tang, Bin Gao, Can Deng, Jianjun Shen, Min Li, Chaolin Fu, Zekun Gao, Zhan Jiang, Qi Shi, Hao He, Miao Jiang, Huaiwu Jia, Xu |
author_sort | Liu, Chao |
collection | PubMed |
description | The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain. |
format | Online Article Text |
id | pubmed-8669593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86695932021-12-15 Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China Liu, Chao Tang, Bin Gao, Can Deng, Jianjun Shen, Min Li, Chaolin Fu, Zekun Gao, Zhan Jiang, Qi Shi, Hao He, Miao Jiang, Huaiwu Jia, Xu Front Med (Lausanne) Medicine The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669593/ /pubmed/34917639 http://dx.doi.org/10.3389/fmed.2021.783646 Text en Copyright © 2021 Liu, Tang, Gao, Deng, Shen, Li, Fu, Gao, Jiang, Shi, He, Jiang and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Liu, Chao Tang, Bin Gao, Can Deng, Jianjun Shen, Min Li, Chaolin Fu, Zekun Gao, Zhan Jiang, Qi Shi, Hao He, Miao Jiang, Huaiwu Jia, Xu Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title | Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title_full | Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title_fullStr | Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title_full_unstemmed | Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title_short | Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
title_sort | case report: genomic characteristics of the first known case of sars-cov-2 imported from spain to sichuan, china |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669593/ https://www.ncbi.nlm.nih.gov/pubmed/34917639 http://dx.doi.org/10.3389/fmed.2021.783646 |
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