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A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles

Multiple myeloma is a heterogeneous plasma cell malignancy that remains incurable because of the tendency of relapse for most patients. Survival outcomes may vary widely due to patient and disease variables; therefore, it is necessary to establish a more accurate prognostic model to improve prognost...

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Autores principales: Chen, Xiaotong, Liu, Lintao, Chen, Mengping, Xiang, Jing, Wan, Yike, Li, Xin, Jiang, Jinxing, Hou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669596/
https://www.ncbi.nlm.nih.gov/pubmed/34917133
http://dx.doi.org/10.3389/fgene.2021.785330
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author Chen, Xiaotong
Liu, Lintao
Chen, Mengping
Xiang, Jing
Wan, Yike
Li, Xin
Jiang, Jinxing
Hou, Jian
author_facet Chen, Xiaotong
Liu, Lintao
Chen, Mengping
Xiang, Jing
Wan, Yike
Li, Xin
Jiang, Jinxing
Hou, Jian
author_sort Chen, Xiaotong
collection PubMed
description Multiple myeloma is a heterogeneous plasma cell malignancy that remains incurable because of the tendency of relapse for most patients. Survival outcomes may vary widely due to patient and disease variables; therefore, it is necessary to establish a more accurate prognostic model to improve prognostic precision and guide clinical therapy. Here, we developed a risk score model based on myeloma gene expression profiles from three independent datasets: GSE6477, GSE13591, and GSE24080. In this model, highly survival-associated five genes, including EPAS1, ERC2, PRC1, CSGALNACT1, and CCND1, are selected by using the least absolute shrinkage and selection operator (Lasso) regression and univariate and multivariate Cox regression analyses. At last, we analyzed three validation datasets (including GSE2658, GSE136337, and MMRF datasets) to examine the prognostic efficacy of this model by dividing patients into high-risk and low-risk groups based on the median risk score. The results indicated that the survival of patients in low-risk group was greatly prolonged compared with their counterparts in the high-risk group. Therefore, the five-gene risk score model could increase the accuracy of risk stratification and provide effective prediction for the prognosis of patients and instruction for individualized clinical treatment.
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spelling pubmed-86695962021-12-15 A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles Chen, Xiaotong Liu, Lintao Chen, Mengping Xiang, Jing Wan, Yike Li, Xin Jiang, Jinxing Hou, Jian Front Genet Genetics Multiple myeloma is a heterogeneous plasma cell malignancy that remains incurable because of the tendency of relapse for most patients. Survival outcomes may vary widely due to patient and disease variables; therefore, it is necessary to establish a more accurate prognostic model to improve prognostic precision and guide clinical therapy. Here, we developed a risk score model based on myeloma gene expression profiles from three independent datasets: GSE6477, GSE13591, and GSE24080. In this model, highly survival-associated five genes, including EPAS1, ERC2, PRC1, CSGALNACT1, and CCND1, are selected by using the least absolute shrinkage and selection operator (Lasso) regression and univariate and multivariate Cox regression analyses. At last, we analyzed three validation datasets (including GSE2658, GSE136337, and MMRF datasets) to examine the prognostic efficacy of this model by dividing patients into high-risk and low-risk groups based on the median risk score. The results indicated that the survival of patients in low-risk group was greatly prolonged compared with their counterparts in the high-risk group. Therefore, the five-gene risk score model could increase the accuracy of risk stratification and provide effective prediction for the prognosis of patients and instruction for individualized clinical treatment. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669596/ /pubmed/34917133 http://dx.doi.org/10.3389/fgene.2021.785330 Text en Copyright © 2021 Chen, Liu, Chen, Xiang, Wan, Li, Jiang and Hou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chen, Xiaotong
Liu, Lintao
Chen, Mengping
Xiang, Jing
Wan, Yike
Li, Xin
Jiang, Jinxing
Hou, Jian
A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title_full A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title_fullStr A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title_full_unstemmed A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title_short A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles
title_sort five-gene risk score model for predicting the prognosis of multiple myeloma patients based on gene expression profiles
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669596/
https://www.ncbi.nlm.nih.gov/pubmed/34917133
http://dx.doi.org/10.3389/fgene.2021.785330
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