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TGF-β Signaling and Resistance to Cancer Therapy

The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple i...

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Autores principales: Zhang, Maoduo, Zhang, Ying Yi, Chen, Yongze, Wang, Jia, Wang, Qiang, Lu, Hezhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669610/
https://www.ncbi.nlm.nih.gov/pubmed/34917620
http://dx.doi.org/10.3389/fcell.2021.786728
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author Zhang, Maoduo
Zhang, Ying Yi
Chen, Yongze
Wang, Jia
Wang, Qiang
Lu, Hezhe
author_facet Zhang, Maoduo
Zhang, Ying Yi
Chen, Yongze
Wang, Jia
Wang, Qiang
Lu, Hezhe
author_sort Zhang, Maoduo
collection PubMed
description The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multiple drug resistance is a major challenge in cancer therapy; emerging evidence indicates that TGF-β signaling may be a key factor in cancer resistance to chemotherapy, targeted therapy and immunotherapy. Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer.
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spelling pubmed-86696102021-12-15 TGF-β Signaling and Resistance to Cancer Therapy Zhang, Maoduo Zhang, Ying Yi Chen, Yongze Wang, Jia Wang, Qiang Lu, Hezhe Front Cell Dev Biol Cell and Developmental Biology The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multiple drug resistance is a major challenge in cancer therapy; emerging evidence indicates that TGF-β signaling may be a key factor in cancer resistance to chemotherapy, targeted therapy and immunotherapy. Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669610/ /pubmed/34917620 http://dx.doi.org/10.3389/fcell.2021.786728 Text en Copyright © 2021 Zhang, Zhang, Chen, Wang, Wang and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Maoduo
Zhang, Ying Yi
Chen, Yongze
Wang, Jia
Wang, Qiang
Lu, Hezhe
TGF-β Signaling and Resistance to Cancer Therapy
title TGF-β Signaling and Resistance to Cancer Therapy
title_full TGF-β Signaling and Resistance to Cancer Therapy
title_fullStr TGF-β Signaling and Resistance to Cancer Therapy
title_full_unstemmed TGF-β Signaling and Resistance to Cancer Therapy
title_short TGF-β Signaling and Resistance to Cancer Therapy
title_sort tgf-β signaling and resistance to cancer therapy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669610/
https://www.ncbi.nlm.nih.gov/pubmed/34917620
http://dx.doi.org/10.3389/fcell.2021.786728
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