Structure–Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

[Image: see text] Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure–activity relationship u...

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Detalles Bibliográficos
Autores principales: Wesseling, Charlotte M. J., Slingerland, Cornelis J., Veraar, Shanice, Lok, Samantha, Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669655/
https://www.ncbi.nlm.nih.gov/pubmed/34766746
http://dx.doi.org/10.1021/acsinfecdis.1c00466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669655/
https://www.ncbi.nlm.nih.gov/pubmed/34766746
http://dx.doi.org/10.1021/acsinfecdis.1c00466

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