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Approaches for completing metabolic networks through metabolite damage and repair discovery

Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites that can be toxic, are mended by dedicated “metabolite repair enzymes.” Deficiencies in the latter...

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Detalles Bibliográficos
Autores principales: Griffith, Corey M., Walvekar, Adhish S., Linster, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669784/
https://www.ncbi.nlm.nih.gov/pubmed/34957344
http://dx.doi.org/10.1016/j.coisb.2021.100379