Cellular Origin(s) of Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial e...

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Autores principales: Edel, Gabriëla G., Schaaf, Gerben, Wijnen, Rene M. H., Tibboel, Dick, Kardon, Gabrielle, Rottier, Robbert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669812/
https://www.ncbi.nlm.nih.gov/pubmed/34917566
http://dx.doi.org/10.3389/fped.2021.804496
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author Edel, Gabriëla G.
Schaaf, Gerben
Wijnen, Rene M. H.
Tibboel, Dick
Kardon, Gabrielle
Rottier, Robbert J.
author_facet Edel, Gabriëla G.
Schaaf, Gerben
Wijnen, Rene M. H.
Tibboel, Dick
Kardon, Gabrielle
Rottier, Robbert J.
author_sort Edel, Gabriëla G.
collection PubMed
description Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.
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spelling pubmed-86698122021-12-15 Cellular Origin(s) of Congenital Diaphragmatic Hernia Edel, Gabriëla G. Schaaf, Gerben Wijnen, Rene M. H. Tibboel, Dick Kardon, Gabrielle Rottier, Robbert J. Front Pediatr Pediatrics Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research. Frontiers Media S.A. 2021-11-30 /pmc/articles/PMC8669812/ /pubmed/34917566 http://dx.doi.org/10.3389/fped.2021.804496 Text en Copyright © 2021 Edel, Schaaf, Wijnen, Tibboel, Kardon and Rottier. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Edel, Gabriëla G.
Schaaf, Gerben
Wijnen, Rene M. H.
Tibboel, Dick
Kardon, Gabrielle
Rottier, Robbert J.
Cellular Origin(s) of Congenital Diaphragmatic Hernia
title Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_full Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_fullStr Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_full_unstemmed Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_short Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_sort cellular origin(s) of congenital diaphragmatic hernia
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669812/
https://www.ncbi.nlm.nih.gov/pubmed/34917566
http://dx.doi.org/10.3389/fped.2021.804496
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