Antigenic drift: Understanding COVID-19

Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I exp...

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Detalles Bibliográficos
Autor principal: Yewdell, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669911/
https://www.ncbi.nlm.nih.gov/pubmed/34910934
http://dx.doi.org/10.1016/j.immuni.2021.11.016
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author Yewdell, Jonathan W.
author_facet Yewdell, Jonathan W.
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description Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of other viruses and discuss the implications for SARS-CoV-2 evolution and immunity.
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spelling pubmed-86699112021-12-14 Antigenic drift: Understanding COVID-19 Yewdell, Jonathan W. Immunity Primer Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of other viruses and discuss the implications for SARS-CoV-2 evolution and immunity. Published by Elsevier Inc. 2021-12-14 2021-12-14 /pmc/articles/PMC8669911/ /pubmed/34910934 http://dx.doi.org/10.1016/j.immuni.2021.11.016 Text en © 2021 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Primer
Yewdell, Jonathan W.
Antigenic drift: Understanding COVID-19
title Antigenic drift: Understanding COVID-19
title_full Antigenic drift: Understanding COVID-19
title_fullStr Antigenic drift: Understanding COVID-19
title_full_unstemmed Antigenic drift: Understanding COVID-19
title_short Antigenic drift: Understanding COVID-19
title_sort antigenic drift: understanding covid-19
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669911/
https://www.ncbi.nlm.nih.gov/pubmed/34910934
http://dx.doi.org/10.1016/j.immuni.2021.11.016
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