Nicotinic receptors as SARS-CoV-2 spike co-receptors?

Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and respiratory diseases. Controversies regarding the association between COVID-19 hospitalizations and smoking suggest that nAChRs may contribute to SARS-CoV-2 respiratory syndrome. We recently detailed the expression...

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Autores principales: Dormoy, Valérian, Perotin, Jeanne-Marie, Gosset, Philippe, Maskos, Uwe, Polette, Myriam, Deslée, Gaëtan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669939/
https://www.ncbi.nlm.nih.gov/pubmed/34924680
http://dx.doi.org/10.1016/j.mehy.2021.110741
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author Dormoy, Valérian
Perotin, Jeanne-Marie
Gosset, Philippe
Maskos, Uwe
Polette, Myriam
Deslée, Gaëtan
author_facet Dormoy, Valérian
Perotin, Jeanne-Marie
Gosset, Philippe
Maskos, Uwe
Polette, Myriam
Deslée, Gaëtan
author_sort Dormoy, Valérian
collection PubMed
description Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and respiratory diseases. Controversies regarding the association between COVID-19 hospitalizations and smoking suggest that nAChRs may contribute to SARS-CoV-2 respiratory syndrome. We recently detailed the expression and localization of all nAChR subunits in the human lung. Since virus association with nAChRs has been shown in the past, we hypothesize that nAChR subunits act as SARS-CoV-2 Spike co-receptors. Based on sequence alignment analysis, we report domains of high molecular similarities in nAChRs with the binding domain of hACE2 for SARS-CoV-2 Spike protein. This hypothesis supported by in silico pilot data provides a rational for the modelling and the in vitro experimental validation of the interaction between SARS-CoV-2 and the nAChRs.
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spelling pubmed-86699392021-12-14 Nicotinic receptors as SARS-CoV-2 spike co-receptors? Dormoy, Valérian Perotin, Jeanne-Marie Gosset, Philippe Maskos, Uwe Polette, Myriam Deslée, Gaëtan Med Hypotheses Article Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and respiratory diseases. Controversies regarding the association between COVID-19 hospitalizations and smoking suggest that nAChRs may contribute to SARS-CoV-2 respiratory syndrome. We recently detailed the expression and localization of all nAChR subunits in the human lung. Since virus association with nAChRs has been shown in the past, we hypothesize that nAChR subunits act as SARS-CoV-2 Spike co-receptors. Based on sequence alignment analysis, we report domains of high molecular similarities in nAChRs with the binding domain of hACE2 for SARS-CoV-2 Spike protein. This hypothesis supported by in silico pilot data provides a rational for the modelling and the in vitro experimental validation of the interaction between SARS-CoV-2 and the nAChRs. Elsevier Ltd. 2022-01 2021-12-14 /pmc/articles/PMC8669939/ /pubmed/34924680 http://dx.doi.org/10.1016/j.mehy.2021.110741 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Dormoy, Valérian
Perotin, Jeanne-Marie
Gosset, Philippe
Maskos, Uwe
Polette, Myriam
Deslée, Gaëtan
Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title_full Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title_fullStr Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title_full_unstemmed Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title_short Nicotinic receptors as SARS-CoV-2 spike co-receptors?
title_sort nicotinic receptors as sars-cov-2 spike co-receptors?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669939/
https://www.ncbi.nlm.nih.gov/pubmed/34924680
http://dx.doi.org/10.1016/j.mehy.2021.110741
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