ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis

Proteolytic targeting chimeras (PROTACs) is a rapid and reversible chemical knockout method. Compared with traditional gene-editing tools, it can avoid potential genetic compensation, misunderstandings caused by spontaneous mutations, or gene knockouts that lead to embryonic death. To study the role...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Li, Xu, Xiao, Xu, Limei, Wen, Caining, Ouyang, Kan, Li, Zigang, Liang, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669996/
https://www.ncbi.nlm.nih.gov/pubmed/34916941
http://dx.doi.org/10.3389/fphar.2021.764154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669996/
https://www.ncbi.nlm.nih.gov/pubmed/34916941
http://dx.doi.org/10.3389/fphar.2021.764154

Ejemplares similares