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ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis

Proteolytic targeting chimeras (PROTACs) is a rapid and reversible chemical knockout method. Compared with traditional gene-editing tools, it can avoid potential genetic compensation, misunderstandings caused by spontaneous mutations, or gene knockouts that lead to embryonic death. To study the role...

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Detalles Bibliográficos
Autores principales:	Duan, Li, Xu, Xiao, Xu, Limei, Wen, Caining, Ouyang, Kan, Li, Zigang, Liang, Yujie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669996/ https://www.ncbi.nlm.nih.gov/pubmed/34916941 http://dx.doi.org/10.3389/fphar.2021.764154

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