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Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report

With the rapid development of immunotherapy, the efficacy and feasibility of neoadjuvant immunotherapy for early resectable non–small-cell lung cancer (NSCLC) has been demonstrated. However, there are still difficulties and controversies in evaluating the efficacy of neoadjuvant immunotherapy. In ou...

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Autores principales: Liu, Yunpeng, Gao, Zhiru, Zhang, Chengbin, Liu, Xing, Liu, Zihao, Lin, Xingyu, Qian, Benxin, Jin, Fukang, Shao, Guoguang, Yang, Zhiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670334/
https://www.ncbi.nlm.nih.gov/pubmed/34419961
http://dx.doi.org/10.1097/CAD.0000000000001204
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author Liu, Yunpeng
Gao, Zhiru
Zhang, Chengbin
Liu, Xing
Liu, Zihao
Lin, Xingyu
Qian, Benxin
Jin, Fukang
Shao, Guoguang
Yang, Zhiguang
author_facet Liu, Yunpeng
Gao, Zhiru
Zhang, Chengbin
Liu, Xing
Liu, Zihao
Lin, Xingyu
Qian, Benxin
Jin, Fukang
Shao, Guoguang
Yang, Zhiguang
author_sort Liu, Yunpeng
collection PubMed
description With the rapid development of immunotherapy, the efficacy and feasibility of neoadjuvant immunotherapy for early resectable non–small-cell lung cancer (NSCLC) has been demonstrated. However, there are still difficulties and controversies in evaluating the efficacy of neoadjuvant immunotherapy. In our report, we described a 43-year-old female patient who was diagnosed with stage IIIA (cT1N2M0) pulmonary adenocarcinoma. After two cycles of neoadjuvant immunotherapy (sintilimab) combined with chemotherapy, according to imaging evaluation, the efficacy of the primary lesion was evaluated as stable disease and the mediastinal lymph nodes were evaluated as partial response. However, the postoperative pathological evaluation showed the primary lesion was pathological complete response and the mediastinal lymph nodes were major pathological response. This indicated that neoadjuvant chemo-immunotherapy was effective for both primary and mediastinal lymph nodes, but regression of the lesions was not synchronous. This study provided a complete process of neoadjuvant treatment, illustrating the effectiveness and safety of neoadjuvant chemo-immunotherapy to a certain extent. It is also suggested that the evaluation of neoadjuvant immunotherapy should be combined with imaging and pathology, and the primary tumor and lymph nodes should be evaluated, respectively.
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spelling pubmed-86703342021-12-15 Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report Liu, Yunpeng Gao, Zhiru Zhang, Chengbin Liu, Xing Liu, Zihao Lin, Xingyu Qian, Benxin Jin, Fukang Shao, Guoguang Yang, Zhiguang Anticancer Drugs Case Reports With the rapid development of immunotherapy, the efficacy and feasibility of neoadjuvant immunotherapy for early resectable non–small-cell lung cancer (NSCLC) has been demonstrated. However, there are still difficulties and controversies in evaluating the efficacy of neoadjuvant immunotherapy. In our report, we described a 43-year-old female patient who was diagnosed with stage IIIA (cT1N2M0) pulmonary adenocarcinoma. After two cycles of neoadjuvant immunotherapy (sintilimab) combined with chemotherapy, according to imaging evaluation, the efficacy of the primary lesion was evaluated as stable disease and the mediastinal lymph nodes were evaluated as partial response. However, the postoperative pathological evaluation showed the primary lesion was pathological complete response and the mediastinal lymph nodes were major pathological response. This indicated that neoadjuvant chemo-immunotherapy was effective for both primary and mediastinal lymph nodes, but regression of the lesions was not synchronous. This study provided a complete process of neoadjuvant treatment, illustrating the effectiveness and safety of neoadjuvant chemo-immunotherapy to a certain extent. It is also suggested that the evaluation of neoadjuvant immunotherapy should be combined with imaging and pathology, and the primary tumor and lymph nodes should be evaluated, respectively. Lippincott Williams & Wilkins 2021-08-20 2022-01 /pmc/articles/PMC8670334/ /pubmed/34419961 http://dx.doi.org/10.1097/CAD.0000000000001204 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Reports
Liu, Yunpeng
Gao, Zhiru
Zhang, Chengbin
Liu, Xing
Liu, Zihao
Lin, Xingyu
Qian, Benxin
Jin, Fukang
Shao, Guoguang
Yang, Zhiguang
Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title_full Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title_fullStr Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title_full_unstemmed Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title_short Asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage IIIA non–small-cell lung cancer: a case report
title_sort asynchrony of primary tumor and mediastinal lymph nodes response after neoadjuvant immunotherapy plus chemotherapy in a patient with stage iiia non–small-cell lung cancer: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670334/
https://www.ncbi.nlm.nih.gov/pubmed/34419961
http://dx.doi.org/10.1097/CAD.0000000000001204
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