Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review

Side effects of afatinib are a problem in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of afatinib-induced hypotension. An 81-year-old man with NSCLC had an epidermal growth factor receptor-positive genotype with the p.L861Q mutation in exo...

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Autores principales: Tang, Zhiwei, Ji, XiuHai, Zhou, Guanghui, Chen, Ruhua, Fen, Yan, Ding, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670351/
https://www.ncbi.nlm.nih.gov/pubmed/34486535
http://dx.doi.org/10.1097/CAD.0000000000001244
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author Tang, Zhiwei
Ji, XiuHai
Zhou, Guanghui
Chen, Ruhua
Fen, Yan
Ding, Hui
author_facet Tang, Zhiwei
Ji, XiuHai
Zhou, Guanghui
Chen, Ruhua
Fen, Yan
Ding, Hui
author_sort Tang, Zhiwei
collection PubMed
description Side effects of afatinib are a problem in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of afatinib-induced hypotension. An 81-year-old man with NSCLC had an epidermal growth factor receptor-positive genotype with the p.L861Q mutation in exon 21. He was administered afatinib (40 mg/day) as anticancer therapy. Hypotension occurred twice after afatinib initiation. He suffered from dizziness and nausea. Blood pressure gradually returned to normal after afatinib cessation. Clinicians should be aware of hypotension in patients with NSCLC after afatinib initiation.
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spelling pubmed-86703512021-12-15 Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review Tang, Zhiwei Ji, XiuHai Zhou, Guanghui Chen, Ruhua Fen, Yan Ding, Hui Anticancer Drugs Case Reports Side effects of afatinib are a problem in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of afatinib-induced hypotension. An 81-year-old man with NSCLC had an epidermal growth factor receptor-positive genotype with the p.L861Q mutation in exon 21. He was administered afatinib (40 mg/day) as anticancer therapy. Hypotension occurred twice after afatinib initiation. He suffered from dizziness and nausea. Blood pressure gradually returned to normal after afatinib cessation. Clinicians should be aware of hypotension in patients with NSCLC after afatinib initiation. Lippincott Williams & Wilkins 2021-09-13 2022-01 /pmc/articles/PMC8670351/ /pubmed/34486535 http://dx.doi.org/10.1097/CAD.0000000000001244 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Reports
Tang, Zhiwei
Ji, XiuHai
Zhou, Guanghui
Chen, Ruhua
Fen, Yan
Ding, Hui
Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title_full Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title_fullStr Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title_full_unstemmed Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title_short Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
title_sort hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670351/
https://www.ncbi.nlm.nih.gov/pubmed/34486535
http://dx.doi.org/10.1097/CAD.0000000000001244
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