Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins

Protein homeostasis is constantly being challenged with protein misfolding that leads to aggregation. Hsp70 is one of the versatile chaperones that interact with misfolded proteins and actively support their folding. Multifunctional Hsp70s are harnessed to specific roles by J-domain proteins (JDPs,...

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Detalles Bibliográficos
Autores principales: Wyszkowski, Hubert, Janta, Anna, Sztangierska, Wiktoria, Obuchowski, Igor, Chamera, Tomasz, Kłosowska, Agnieszka, Liberek, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670446/
https://www.ncbi.nlm.nih.gov/pubmed/34873058
http://dx.doi.org/10.1073/pnas.2108163118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670446/
https://www.ncbi.nlm.nih.gov/pubmed/34873058
http://dx.doi.org/10.1073/pnas.2108163118

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