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Kinematic self-replication in reconfigurable organisms

All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of...

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Detalles Bibliográficos
Autores principales: Kriegman, Sam, Blackiston, Douglas, Levin, Michael, Bongard, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670470/
https://www.ncbi.nlm.nih.gov/pubmed/34845026
http://dx.doi.org/10.1073/pnas.2112672118
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author Kriegman, Sam
Blackiston, Douglas
Levin, Michael
Bongard, Josh
author_facet Kriegman, Sam
Blackiston, Douglas
Levin, Michael
Bongard, Josh
author_sort Kriegman, Sam
collection PubMed
description All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized.
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spelling pubmed-86704702021-12-28 Kinematic self-replication in reconfigurable organisms Kriegman, Sam Blackiston, Douglas Levin, Michael Bongard, Josh Proc Natl Acad Sci U S A Biological Sciences All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized. National Academy of Sciences 2021-11-29 2021-12-07 /pmc/articles/PMC8670470/ /pubmed/34845026 http://dx.doi.org/10.1073/pnas.2112672118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Kriegman, Sam
Blackiston, Douglas
Levin, Michael
Bongard, Josh
Kinematic self-replication in reconfigurable organisms
title Kinematic self-replication in reconfigurable organisms
title_full Kinematic self-replication in reconfigurable organisms
title_fullStr Kinematic self-replication in reconfigurable organisms
title_full_unstemmed Kinematic self-replication in reconfigurable organisms
title_short Kinematic self-replication in reconfigurable organisms
title_sort kinematic self-replication in reconfigurable organisms
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670470/
https://www.ncbi.nlm.nih.gov/pubmed/34845026
http://dx.doi.org/10.1073/pnas.2112672118
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