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Kinematic self-replication in reconfigurable organisms
All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670470/ https://www.ncbi.nlm.nih.gov/pubmed/34845026 http://dx.doi.org/10.1073/pnas.2112672118 |
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author | Kriegman, Sam Blackiston, Douglas Levin, Michael Bongard, Josh |
author_facet | Kriegman, Sam Blackiston, Douglas Levin, Michael Bongard, Josh |
author_sort | Kriegman, Sam |
collection | PubMed |
description | All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized. |
format | Online Article Text |
id | pubmed-8670470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-86704702021-12-28 Kinematic self-replication in reconfigurable organisms Kriegman, Sam Blackiston, Douglas Levin, Michael Bongard, Josh Proc Natl Acad Sci U S A Biological Sciences All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized. National Academy of Sciences 2021-11-29 2021-12-07 /pmc/articles/PMC8670470/ /pubmed/34845026 http://dx.doi.org/10.1073/pnas.2112672118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Kriegman, Sam Blackiston, Douglas Levin, Michael Bongard, Josh Kinematic self-replication in reconfigurable organisms |
title | Kinematic self-replication in reconfigurable organisms |
title_full | Kinematic self-replication in reconfigurable organisms |
title_fullStr | Kinematic self-replication in reconfigurable organisms |
title_full_unstemmed | Kinematic self-replication in reconfigurable organisms |
title_short | Kinematic self-replication in reconfigurable organisms |
title_sort | kinematic self-replication in reconfigurable organisms |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670470/ https://www.ncbi.nlm.nih.gov/pubmed/34845026 http://dx.doi.org/10.1073/pnas.2112672118 |
work_keys_str_mv | AT kriegmansam kinematicselfreplicationinreconfigurableorganisms AT blackistondouglas kinematicselfreplicationinreconfigurableorganisms AT levinmichael kinematicselfreplicationinreconfigurableorganisms AT bongardjosh kinematicselfreplicationinreconfigurableorganisms |