Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication

As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping machinery to ensure the efficient translation of their messenger RNAs (mRNAs), protect them from degradation by cellular 5′ exoribonucleases (ExoNs), and escape innate immune sensing. The CoV nonstructural p...

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Detalles Bibliográficos
Autores principales: Ogando, Natacha S., El Kazzi, Priscila, Zevenhoven-Dobbe, Jessika C., Bontes, Brenda W., Decombe, Alice, Posthuma, Clara C., Thiel, Volker, Canard, Bruno, Ferron, François, Decroly, Etienne, Snijder, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670481/
https://www.ncbi.nlm.nih.gov/pubmed/34845015
http://dx.doi.org/10.1073/pnas.2108709118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670481/
https://www.ncbi.nlm.nih.gov/pubmed/34845015
http://dx.doi.org/10.1073/pnas.2108709118

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