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Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet st...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670690/ https://www.ncbi.nlm.nih.gov/pubmed/34905546 http://dx.doi.org/10.1371/journal.pone.0259862 |
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author | Fransson, Per-Anders Nilsson, Maria H. Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Patel, Mitesh |
author_facet | Fransson, Per-Anders Nilsson, Maria H. Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Patel, Mitesh |
author_sort | Fransson, Per-Anders |
collection | PubMed |
description | Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet standing and during balance perturbations. Ten patients with PD and 25 young and 17 old control participants were recruited. Body position was measured with 3D motion tracking of the ankle, knee, hip, shoulder and head. By taking the ankle as reference, we mapped the position of the joints during quiet standing and balance perturbations through repeated calf muscle vibration. We did this to explore the effect of PD, DBS in the STN, and vision on the motor learning process of adaptation in response to the repeated stimulus. We found that patients with PD adopt a different body position with DBS ON vs. DBS OFF, to young and old controls, and with eyes open vs. eyes closed. There was an altered body position in PD with greater flexion of the head, shoulder and knee (p≤0.042) and a posterior position of the hip with DBS OFF (p≤0.014). With DBS ON, body position was brought more in line with the position taken by control participants but there was still evidence of greater flexion at the head, shoulder and knee. The amplitude of movement during the vibration period decreased in controls at all measured sites with eyes open and closed (except at the head in old controls with eyes open) showing adaptation which contrasted the weaker adaptive responses in patients with PD. Our findings suggest that alterations of posture and greater forward leaning with repeated calf vibration, are independent from reduced movement amplitude changes. DBS in the STN can significantly improve body position in PD although the effects are not completely reversed. Patients with PD maintain adaptive capabilities by leaning further forward and reducing movement amplitude despite their kyphotic posture. |
format | Online Article Text |
id | pubmed-8670690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86706902021-12-15 Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease Fransson, Per-Anders Nilsson, Maria H. Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Patel, Mitesh PLoS One Research Article Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet standing and during balance perturbations. Ten patients with PD and 25 young and 17 old control participants were recruited. Body position was measured with 3D motion tracking of the ankle, knee, hip, shoulder and head. By taking the ankle as reference, we mapped the position of the joints during quiet standing and balance perturbations through repeated calf muscle vibration. We did this to explore the effect of PD, DBS in the STN, and vision on the motor learning process of adaptation in response to the repeated stimulus. We found that patients with PD adopt a different body position with DBS ON vs. DBS OFF, to young and old controls, and with eyes open vs. eyes closed. There was an altered body position in PD with greater flexion of the head, shoulder and knee (p≤0.042) and a posterior position of the hip with DBS OFF (p≤0.014). With DBS ON, body position was brought more in line with the position taken by control participants but there was still evidence of greater flexion at the head, shoulder and knee. The amplitude of movement during the vibration period decreased in controls at all measured sites with eyes open and closed (except at the head in old controls with eyes open) showing adaptation which contrasted the weaker adaptive responses in patients with PD. Our findings suggest that alterations of posture and greater forward leaning with repeated calf vibration, are independent from reduced movement amplitude changes. DBS in the STN can significantly improve body position in PD although the effects are not completely reversed. Patients with PD maintain adaptive capabilities by leaning further forward and reducing movement amplitude despite their kyphotic posture. Public Library of Science 2021-12-14 /pmc/articles/PMC8670690/ /pubmed/34905546 http://dx.doi.org/10.1371/journal.pone.0259862 Text en © 2021 Fransson et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fransson, Per-Anders Nilsson, Maria H. Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Patel, Mitesh Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title | Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title_full | Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title_fullStr | Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title_full_unstemmed | Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title_short | Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease |
title_sort | deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in parkinson’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670690/ https://www.ncbi.nlm.nih.gov/pubmed/34905546 http://dx.doi.org/10.1371/journal.pone.0259862 |
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