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Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease

Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet st...

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Autores principales: Fransson, Per-Anders, Nilsson, Maria H., Rehncrona, Stig, Tjernström, Fredrik, Magnusson, Måns, Johansson, Rolf, Patel, Mitesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670690/
https://www.ncbi.nlm.nih.gov/pubmed/34905546
http://dx.doi.org/10.1371/journal.pone.0259862
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author Fransson, Per-Anders
Nilsson, Maria H.
Rehncrona, Stig
Tjernström, Fredrik
Magnusson, Måns
Johansson, Rolf
Patel, Mitesh
author_facet Fransson, Per-Anders
Nilsson, Maria H.
Rehncrona, Stig
Tjernström, Fredrik
Magnusson, Måns
Johansson, Rolf
Patel, Mitesh
author_sort Fransson, Per-Anders
collection PubMed
description Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet standing and during balance perturbations. Ten patients with PD and 25 young and 17 old control participants were recruited. Body position was measured with 3D motion tracking of the ankle, knee, hip, shoulder and head. By taking the ankle as reference, we mapped the position of the joints during quiet standing and balance perturbations through repeated calf muscle vibration. We did this to explore the effect of PD, DBS in the STN, and vision on the motor learning process of adaptation in response to the repeated stimulus. We found that patients with PD adopt a different body position with DBS ON vs. DBS OFF, to young and old controls, and with eyes open vs. eyes closed. There was an altered body position in PD with greater flexion of the head, shoulder and knee (p≤0.042) and a posterior position of the hip with DBS OFF (p≤0.014). With DBS ON, body position was brought more in line with the position taken by control participants but there was still evidence of greater flexion at the head, shoulder and knee. The amplitude of movement during the vibration period decreased in controls at all measured sites with eyes open and closed (except at the head in old controls with eyes open) showing adaptation which contrasted the weaker adaptive responses in patients with PD. Our findings suggest that alterations of posture and greater forward leaning with repeated calf vibration, are independent from reduced movement amplitude changes. DBS in the STN can significantly improve body position in PD although the effects are not completely reversed. Patients with PD maintain adaptive capabilities by leaning further forward and reducing movement amplitude despite their kyphotic posture.
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spelling pubmed-86706902021-12-15 Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease Fransson, Per-Anders Nilsson, Maria H. Rehncrona, Stig Tjernström, Fredrik Magnusson, Måns Johansson, Rolf Patel, Mitesh PLoS One Research Article Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet standing and during balance perturbations. Ten patients with PD and 25 young and 17 old control participants were recruited. Body position was measured with 3D motion tracking of the ankle, knee, hip, shoulder and head. By taking the ankle as reference, we mapped the position of the joints during quiet standing and balance perturbations through repeated calf muscle vibration. We did this to explore the effect of PD, DBS in the STN, and vision on the motor learning process of adaptation in response to the repeated stimulus. We found that patients with PD adopt a different body position with DBS ON vs. DBS OFF, to young and old controls, and with eyes open vs. eyes closed. There was an altered body position in PD with greater flexion of the head, shoulder and knee (p≤0.042) and a posterior position of the hip with DBS OFF (p≤0.014). With DBS ON, body position was brought more in line with the position taken by control participants but there was still evidence of greater flexion at the head, shoulder and knee. The amplitude of movement during the vibration period decreased in controls at all measured sites with eyes open and closed (except at the head in old controls with eyes open) showing adaptation which contrasted the weaker adaptive responses in patients with PD. Our findings suggest that alterations of posture and greater forward leaning with repeated calf vibration, are independent from reduced movement amplitude changes. DBS in the STN can significantly improve body position in PD although the effects are not completely reversed. Patients with PD maintain adaptive capabilities by leaning further forward and reducing movement amplitude despite their kyphotic posture. Public Library of Science 2021-12-14 /pmc/articles/PMC8670690/ /pubmed/34905546 http://dx.doi.org/10.1371/journal.pone.0259862 Text en © 2021 Fransson et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fransson, Per-Anders
Nilsson, Maria H.
Rehncrona, Stig
Tjernström, Fredrik
Magnusson, Måns
Johansson, Rolf
Patel, Mitesh
Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title_full Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title_fullStr Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title_full_unstemmed Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title_short Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson’s disease
title_sort deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670690/
https://www.ncbi.nlm.nih.gov/pubmed/34905546
http://dx.doi.org/10.1371/journal.pone.0259862
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