The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour

The SARS-CoV-2 spike protein is the first contact point between the SARS-CoV-2 virus and host cells and mediates membrane fusion. Recently, a fatty acid binding site was identified in the spike (Toelzer et al. Science 2020). The presence of linoleic acid at this site modulates binding of the spike t...

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Detalles Bibliográficos
Autores principales: Sofia F. Oliveira, A., Shoemark, Deborah K., Avila Ibarra, Amaurys, Davidson, Andrew D., Berger, Imre, Schaffitzel, Christiane, Mulholland, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670790/
https://www.ncbi.nlm.nih.gov/pubmed/34934478
http://dx.doi.org/10.1016/j.csbj.2021.12.011

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