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Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys

BACKGROUND: Torsion of the testis is an urgent surgical condition that endangers the viability of the gonad and the fertility of the patient. Our aim was to assess potential autoimmune processes and hormonal abnormalities in boys operated on due to that illness. METHODS: The authors evaluated the le...

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Autores principales: Osemlak, Paweł, Miszczuk, Konrad, Jędrzejewski, Grzegorz, Nachulewicz, Paweł, Beń-Skowronek, Iwona, Brzozowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671086/
https://www.ncbi.nlm.nih.gov/pubmed/33603210
http://dx.doi.org/10.1038/s41390-021-01382-0
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author Osemlak, Paweł
Miszczuk, Konrad
Jędrzejewski, Grzegorz
Nachulewicz, Paweł
Beń-Skowronek, Iwona
Brzozowska, Agnieszka
author_facet Osemlak, Paweł
Miszczuk, Konrad
Jędrzejewski, Grzegorz
Nachulewicz, Paweł
Beń-Skowronek, Iwona
Brzozowska, Agnieszka
author_sort Osemlak, Paweł
collection PubMed
description BACKGROUND: Torsion of the testis is an urgent surgical condition that endangers the viability of the gonad and the fertility of the patient. Our aim was to assess potential autoimmune processes and hormonal abnormalities in boys operated on due to that illness. METHODS: The authors evaluated the levels of antibodies against sperm and Leydig cells, concentrations of follicle-stimulating, luteinizing and anti-Müllerian hormone, testosterone, oestradiol and vascular endothelial growth factor in the serum in 28 boys operated on due to torsion of the testis. Patients’ sexual maturity was assessed according the Tanner scale (group G1, G4 and G5). RESULTS: No antibodies against sperm or Leydig cells were found in the serum. Statistically significant differences in follicle-stimulating and anti-Müllerian hormone concentrations were observed in the G1, and they were higher in the study than in the control group. There were no statistically significant differences in luteinizing hormone, testosterone, oestradiol and vascular endothelial growth factor concentrations in the study group or control group. Testosterone concentration was unrelated to total testicular volume. CONCLUSIONS: Results did not confirm the autoimmune process in boys with torsion of the testis. The pituitary–testis axis seems to have sufficient compensation capabilities. However, study results suggest that primary gonadal dysfunction may predispose to torsion. IMPACT: Significant differences exist between the literature data and own results on the formation of antibodies and hormonal changes due to testicular torsion in boys. It is a novel, prospective study on antibodies against sperms and Leydig cells in the serum and on hormonal processes occurring as a result of the testicular torsion from the prenatal period to the adolescence with division into pubertal groups. The study has revealed sufficient compensation capabilities of the pituitary–testis axis and no autoimmune process in boys with torsion of the testis.
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spelling pubmed-86710862021-12-29 Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys Osemlak, Paweł Miszczuk, Konrad Jędrzejewski, Grzegorz Nachulewicz, Paweł Beń-Skowronek, Iwona Brzozowska, Agnieszka Pediatr Res Clinical Research Article BACKGROUND: Torsion of the testis is an urgent surgical condition that endangers the viability of the gonad and the fertility of the patient. Our aim was to assess potential autoimmune processes and hormonal abnormalities in boys operated on due to that illness. METHODS: The authors evaluated the levels of antibodies against sperm and Leydig cells, concentrations of follicle-stimulating, luteinizing and anti-Müllerian hormone, testosterone, oestradiol and vascular endothelial growth factor in the serum in 28 boys operated on due to torsion of the testis. Patients’ sexual maturity was assessed according the Tanner scale (group G1, G4 and G5). RESULTS: No antibodies against sperm or Leydig cells were found in the serum. Statistically significant differences in follicle-stimulating and anti-Müllerian hormone concentrations were observed in the G1, and they were higher in the study than in the control group. There were no statistically significant differences in luteinizing hormone, testosterone, oestradiol and vascular endothelial growth factor concentrations in the study group or control group. Testosterone concentration was unrelated to total testicular volume. CONCLUSIONS: Results did not confirm the autoimmune process in boys with torsion of the testis. The pituitary–testis axis seems to have sufficient compensation capabilities. However, study results suggest that primary gonadal dysfunction may predispose to torsion. IMPACT: Significant differences exist between the literature data and own results on the formation of antibodies and hormonal changes due to testicular torsion in boys. It is a novel, prospective study on antibodies against sperms and Leydig cells in the serum and on hormonal processes occurring as a result of the testicular torsion from the prenatal period to the adolescence with division into pubertal groups. The study has revealed sufficient compensation capabilities of the pituitary–testis axis and no autoimmune process in boys with torsion of the testis. Nature Publishing Group US 2021-02-18 2021 /pmc/articles/PMC8671086/ /pubmed/33603210 http://dx.doi.org/10.1038/s41390-021-01382-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Research Article
Osemlak, Paweł
Miszczuk, Konrad
Jędrzejewski, Grzegorz
Nachulewicz, Paweł
Beń-Skowronek, Iwona
Brzozowska, Agnieszka
Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title_full Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title_fullStr Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title_full_unstemmed Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title_short Testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
title_sort testicular torsion: its effect on autoimmunisation, pituitary–testis axis and correlation with primary gonadal dysfunction in boys
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671086/
https://www.ncbi.nlm.nih.gov/pubmed/33603210
http://dx.doi.org/10.1038/s41390-021-01382-0
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