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Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions
The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration. However, cartilage defects are considerably more complicated in clinical conditions, especially when injuries occur at specific sites (e.g., osteochondral tissue, grow...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671106/ https://www.ncbi.nlm.nih.gov/pubmed/34977434 http://dx.doi.org/10.1016/j.bioactmat.2021.10.002 |
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author | Wang, Zhonghan Le, Hanxiang Wang, Yanbing Liu, He Li, Zuhao Yang, Xiaoyu Wang, Chenyu Ding, Jianxun Chen, Xuesi |
author_facet | Wang, Zhonghan Le, Hanxiang Wang, Yanbing Liu, He Li, Zuhao Yang, Xiaoyu Wang, Chenyu Ding, Jianxun Chen, Xuesi |
author_sort | Wang, Zhonghan |
collection | PubMed |
description | The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration. However, cartilage defects are considerably more complicated in clinical conditions, especially when injuries occur at specific sites (e.g., osteochondral tissue, growth plate, and weight-bearing area) or under inflammatory microenvironments (e.g., osteoarthritis and rheumatoid arthritis). Therapeutic implantations, including advanced scaffolds, developed growth factors, and various cells alone or in combination currently used to treat cartilage lesions, address cartilage regeneration under abnormal conditions. This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation. |
format | Online Article Text |
id | pubmed-8671106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-86711062021-12-30 Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions Wang, Zhonghan Le, Hanxiang Wang, Yanbing Liu, He Li, Zuhao Yang, Xiaoyu Wang, Chenyu Ding, Jianxun Chen, Xuesi Bioact Mater Article The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration. However, cartilage defects are considerably more complicated in clinical conditions, especially when injuries occur at specific sites (e.g., osteochondral tissue, growth plate, and weight-bearing area) or under inflammatory microenvironments (e.g., osteoarthritis and rheumatoid arthritis). Therapeutic implantations, including advanced scaffolds, developed growth factors, and various cells alone or in combination currently used to treat cartilage lesions, address cartilage regeneration under abnormal conditions. This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation. KeAi Publishing 2021-11-18 /pmc/articles/PMC8671106/ /pubmed/34977434 http://dx.doi.org/10.1016/j.bioactmat.2021.10.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Zhonghan Le, Hanxiang Wang, Yanbing Liu, He Li, Zuhao Yang, Xiaoyu Wang, Chenyu Ding, Jianxun Chen, Xuesi Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title_full | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title_fullStr | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title_full_unstemmed | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title_short | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
title_sort | instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671106/ https://www.ncbi.nlm.nih.gov/pubmed/34977434 http://dx.doi.org/10.1016/j.bioactmat.2021.10.002 |
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