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Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma

OBJECTIVES: Mucinous breast cancer (MBC), particularly pure MBC (pMBC), often tend to be confused with fibroadenoma (FA) due to their similar images and firm masses, so some MBC cases are misdiagnosed to be FA, which may cause poor prognosis. We analyzed the ultrasonic features and aimed to identify...

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Autores principales: Liang, Ting, Shen, Junhui, Zhang, Shumei, Cong, Shuzhen, Liu, Juanjuan, Pei, Shufang, Shang, Shiyao, Huang, Chunwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671140/
https://www.ncbi.nlm.nih.gov/pubmed/34926246
http://dx.doi.org/10.3389/fonc.2021.724656
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author Liang, Ting
Shen, Junhui
Zhang, Shumei
Cong, Shuzhen
Liu, Juanjuan
Pei, Shufang
Shang, Shiyao
Huang, Chunwang
author_facet Liang, Ting
Shen, Junhui
Zhang, Shumei
Cong, Shuzhen
Liu, Juanjuan
Pei, Shufang
Shang, Shiyao
Huang, Chunwang
author_sort Liang, Ting
collection PubMed
description OBJECTIVES: Mucinous breast cancer (MBC), particularly pure MBC (pMBC), often tend to be confused with fibroadenoma (FA) due to their similar images and firm masses, so some MBC cases are misdiagnosed to be FA, which may cause poor prognosis. We analyzed the ultrasonic features and aimed to identify the ability of multilayer perceptron (MLP) to classify early MBC and its subtypes and FA. MATERIALS AND METHODS: The study consisted of 193 patients diagnosed with pMBC, mMBC, or FA. The area under curve (AUC) was calculated to assess the effectiveness of age and 10 ultrasound features in differentiating MBC from FA. We used the pairwise comparison to examine the differences among MBC subtypes (pure and mixed types) and FA. We utilized the MLP to differentiate MBC and its subtypes from FA. RESULTS: The nine features with AUCs over 0.5 were as follows: age, echo pattern, shape, orientation, margin, echo rim, vascularity distribution, vascularity grade, and tumor size. In subtype analysis, the significant differences were obtained in 10 variables (p-value range, 0.000–0.037) among pMBC, mMBC, and FA, except posterior feature. Through MLP, the AUCs of predicting MBC and FA were both 0.919; the AUCs of predicting pMBC, mMBC, and FA were 0.875, 0.767, and 0.927, respectively. CONCLUSION: Our study found that the MLP models based on ultrasonic characteristics and age can well distinguish MBC and its subtypes from FA. It may provide a critical insight into MBC preoperative clinical management.
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spelling pubmed-86711402021-12-16 Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma Liang, Ting Shen, Junhui Zhang, Shumei Cong, Shuzhen Liu, Juanjuan Pei, Shufang Shang, Shiyao Huang, Chunwang Front Oncol Oncology OBJECTIVES: Mucinous breast cancer (MBC), particularly pure MBC (pMBC), often tend to be confused with fibroadenoma (FA) due to their similar images and firm masses, so some MBC cases are misdiagnosed to be FA, which may cause poor prognosis. We analyzed the ultrasonic features and aimed to identify the ability of multilayer perceptron (MLP) to classify early MBC and its subtypes and FA. MATERIALS AND METHODS: The study consisted of 193 patients diagnosed with pMBC, mMBC, or FA. The area under curve (AUC) was calculated to assess the effectiveness of age and 10 ultrasound features in differentiating MBC from FA. We used the pairwise comparison to examine the differences among MBC subtypes (pure and mixed types) and FA. We utilized the MLP to differentiate MBC and its subtypes from FA. RESULTS: The nine features with AUCs over 0.5 were as follows: age, echo pattern, shape, orientation, margin, echo rim, vascularity distribution, vascularity grade, and tumor size. In subtype analysis, the significant differences were obtained in 10 variables (p-value range, 0.000–0.037) among pMBC, mMBC, and FA, except posterior feature. Through MLP, the AUCs of predicting MBC and FA were both 0.919; the AUCs of predicting pMBC, mMBC, and FA were 0.875, 0.767, and 0.927, respectively. CONCLUSION: Our study found that the MLP models based on ultrasonic characteristics and age can well distinguish MBC and its subtypes from FA. It may provide a critical insight into MBC preoperative clinical management. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8671140/ /pubmed/34926246 http://dx.doi.org/10.3389/fonc.2021.724656 Text en Copyright © 2021 Liang, Shen, Zhang, Cong, Liu, Pei, Shang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liang, Ting
Shen, Junhui
Zhang, Shumei
Cong, Shuzhen
Liu, Juanjuan
Pei, Shufang
Shang, Shiyao
Huang, Chunwang
Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title_full Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title_fullStr Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title_full_unstemmed Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title_short Using Ultrasound-Based Multilayer Perceptron to Differentiate Early Breast Mucinous Cancer and its Subtypes From Fibroadenoma
title_sort using ultrasound-based multilayer perceptron to differentiate early breast mucinous cancer and its subtypes from fibroadenoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671140/
https://www.ncbi.nlm.nih.gov/pubmed/34926246
http://dx.doi.org/10.3389/fonc.2021.724656
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