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Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development

Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve th...

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Autores principales: Perez-García, Patricia, Pardillo-Díaz, Ricardo, Geribaldi-Doldán, Noelia, Gómez-Oliva, Ricardo, Domínguez-García, Samuel, Castro, Carmen, Nunez-Abades, Pedro, Carrascal, Livia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671142/
https://www.ncbi.nlm.nih.gov/pubmed/34924951
http://dx.doi.org/10.3389/fnmol.2021.754393
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author Perez-García, Patricia
Pardillo-Díaz, Ricardo
Geribaldi-Doldán, Noelia
Gómez-Oliva, Ricardo
Domínguez-García, Samuel
Castro, Carmen
Nunez-Abades, Pedro
Carrascal, Livia
author_facet Perez-García, Patricia
Pardillo-Díaz, Ricardo
Geribaldi-Doldán, Noelia
Gómez-Oliva, Ricardo
Domínguez-García, Samuel
Castro, Carmen
Nunez-Abades, Pedro
Carrascal, Livia
author_sort Perez-García, Patricia
collection PubMed
description Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve these complex tasks. Understanding how the neuronal membrane properties and circuits change during development is the first step to understand their transition into efficient ones. Thus, using whole cell patch clamp recordings, we have studied the changes in the electrophysiological properties of layer V pyramidal neurons of the rat primary motor cortex during postnatal development. Among all the parameters studied, only the voltage threshold was established at birth and, although some of the changes occurred mainly during the second postnatal week, other properties such as membrane potential, capacitance, duration of the post-hyperpolarization phase or the maximum firing rate were not defined until the beginning of adulthood. Those modifications lead to a decrease in neuronal excitability and to an increase in the working range in young adult neurons, allowing more sensitive and accurate responses. This maturation process, that involves an increase in neuronal size and changes in ionic conductances, seems to be influenced by the neuronal type and by the task that neurons perform as inferred from the comparison with other pyramidal and motor neuron populations.
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spelling pubmed-86711422021-12-16 Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development Perez-García, Patricia Pardillo-Díaz, Ricardo Geribaldi-Doldán, Noelia Gómez-Oliva, Ricardo Domínguez-García, Samuel Castro, Carmen Nunez-Abades, Pedro Carrascal, Livia Front Mol Neurosci Neuroscience Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve these complex tasks. Understanding how the neuronal membrane properties and circuits change during development is the first step to understand their transition into efficient ones. Thus, using whole cell patch clamp recordings, we have studied the changes in the electrophysiological properties of layer V pyramidal neurons of the rat primary motor cortex during postnatal development. Among all the parameters studied, only the voltage threshold was established at birth and, although some of the changes occurred mainly during the second postnatal week, other properties such as membrane potential, capacitance, duration of the post-hyperpolarization phase or the maximum firing rate were not defined until the beginning of adulthood. Those modifications lead to a decrease in neuronal excitability and to an increase in the working range in young adult neurons, allowing more sensitive and accurate responses. This maturation process, that involves an increase in neuronal size and changes in ionic conductances, seems to be influenced by the neuronal type and by the task that neurons perform as inferred from the comparison with other pyramidal and motor neuron populations. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8671142/ /pubmed/34924951 http://dx.doi.org/10.3389/fnmol.2021.754393 Text en Copyright © 2021 Perez-García, Pardillo-Díaz, Geribaldi-Doldán, Gómez-Oliva, Domínguez-García, Castro, Nunez-Abades and Carrascal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Perez-García, Patricia
Pardillo-Díaz, Ricardo
Geribaldi-Doldán, Noelia
Gómez-Oliva, Ricardo
Domínguez-García, Samuel
Castro, Carmen
Nunez-Abades, Pedro
Carrascal, Livia
Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title_full Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title_fullStr Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title_full_unstemmed Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title_short Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development
title_sort refinement of active and passive membrane properties of layer v pyramidal neurons in rat primary motor cortex during postnatal development
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671142/
https://www.ncbi.nlm.nih.gov/pubmed/34924951
http://dx.doi.org/10.3389/fnmol.2021.754393
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