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Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation

Epidemiological studies show strong associations between fine particulate matter (PM(2.5)) air pollution and adverse pulmonary effects. In the present study, wintertime PM(2.5) samples were collected from three geographically similar regions—Sacramento, California, USA; Jinan, Shandong, China; and T...

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Autores principales: Yuan, Wanjun, Velasquez, Sandra C., Wu, Ching-Wen, Fulgar, Ciara C., Zhang, Qi, Young, Dominique E., Bein, Keith J., Vogel, Christoph F.A., Li, Wei, Cui, Liangliang, Wei, Haiying, Pinkerton, Kent E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671358/
https://www.ncbi.nlm.nih.gov/pubmed/34757175
http://dx.doi.org/10.1016/j.toxlet.2021.10.014
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author Yuan, Wanjun
Velasquez, Sandra C.
Wu, Ching-Wen
Fulgar, Ciara C.
Zhang, Qi
Young, Dominique E.
Bein, Keith J.
Vogel, Christoph F.A.
Li, Wei
Cui, Liangliang
Wei, Haiying
Pinkerton, Kent E.
author_facet Yuan, Wanjun
Velasquez, Sandra C.
Wu, Ching-Wen
Fulgar, Ciara C.
Zhang, Qi
Young, Dominique E.
Bein, Keith J.
Vogel, Christoph F.A.
Li, Wei
Cui, Liangliang
Wei, Haiying
Pinkerton, Kent E.
author_sort Yuan, Wanjun
collection PubMed
description Epidemiological studies show strong associations between fine particulate matter (PM(2.5)) air pollution and adverse pulmonary effects. In the present study, wintertime PM(2.5) samples were collected from three geographically similar regions—Sacramento, California, USA; Jinan, Shandong, China; and Taiyuan, Shanxi, China—and extracted to form PM(CA), PM(SD), and PM(SX), respectively, for comparison in a BALB/c mouse model. Each of four groups was oropharyngeally administered Milli-Q water vehicle control (50 μ L) or one type of PM extract (20 μg/50 μL) five times over two weeks. Mice were necropsied on post-exposure days 1, 2, and 4 and examined using bronchoalveolar lavage (BAL), histopathology, and assessments of cytokine/chemokine mRNA and protein expression. Chemical analysis demonstrated all three extracts contained black carbon, but PM(SX) contained more sulfates and polycyclic aromatic hydrocarbons (PAHs) associated with significantly greater neutrophil numbers and greater alveolar/bronchiolar inflammation on post-exposure days 1 and 4. On day 4, PM(SX)-exposed mice also exhibited significant increases in interleukin-1 beta, tumor necrosis factor-alpha, and chemokine C-X-C motif ligands-3 and −5 mRNA, and monocyte chemoattractant protein-1 protein. These combined findings suggest greater sulfate and PAH content contributed to a more intense and progressive inflammatory response with repeated PM(SX) compared to PM(CA) or PM(SD) exposure.
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spelling pubmed-86713582022-01-01 Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation Yuan, Wanjun Velasquez, Sandra C. Wu, Ching-Wen Fulgar, Ciara C. Zhang, Qi Young, Dominique E. Bein, Keith J. Vogel, Christoph F.A. Li, Wei Cui, Liangliang Wei, Haiying Pinkerton, Kent E. Toxicol Lett Article Epidemiological studies show strong associations between fine particulate matter (PM(2.5)) air pollution and adverse pulmonary effects. In the present study, wintertime PM(2.5) samples were collected from three geographically similar regions—Sacramento, California, USA; Jinan, Shandong, China; and Taiyuan, Shanxi, China—and extracted to form PM(CA), PM(SD), and PM(SX), respectively, for comparison in a BALB/c mouse model. Each of four groups was oropharyngeally administered Milli-Q water vehicle control (50 μ L) or one type of PM extract (20 μg/50 μL) five times over two weeks. Mice were necropsied on post-exposure days 1, 2, and 4 and examined using bronchoalveolar lavage (BAL), histopathology, and assessments of cytokine/chemokine mRNA and protein expression. Chemical analysis demonstrated all three extracts contained black carbon, but PM(SX) contained more sulfates and polycyclic aromatic hydrocarbons (PAHs) associated with significantly greater neutrophil numbers and greater alveolar/bronchiolar inflammation on post-exposure days 1 and 4. On day 4, PM(SX)-exposed mice also exhibited significant increases in interleukin-1 beta, tumor necrosis factor-alpha, and chemokine C-X-C motif ligands-3 and −5 mRNA, and monocyte chemoattractant protein-1 protein. These combined findings suggest greater sulfate and PAH content contributed to a more intense and progressive inflammatory response with repeated PM(SX) compared to PM(CA) or PM(SD) exposure. 2021-10-29 2022-01-01 /pmc/articles/PMC8671358/ /pubmed/34757175 http://dx.doi.org/10.1016/j.toxlet.2021.10.014 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Yuan, Wanjun
Velasquez, Sandra C.
Wu, Ching-Wen
Fulgar, Ciara C.
Zhang, Qi
Young, Dominique E.
Bein, Keith J.
Vogel, Christoph F.A.
Li, Wei
Cui, Liangliang
Wei, Haiying
Pinkerton, Kent E.
Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title_full Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title_fullStr Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title_full_unstemmed Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title_short Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation
title_sort pulmonary health effects of wintertime particulate matter from california and china following repeated exposure and cessation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671358/
https://www.ncbi.nlm.nih.gov/pubmed/34757175
http://dx.doi.org/10.1016/j.toxlet.2021.10.014
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