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Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020

Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which seriously threatens the healthy development of the poultry industry. Since its spread to China in the early 1990s, the very virulent IBDV (vvIBDV) c...

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Autores principales: Jiang, Nan, Wang, Yulong, Zhang, Wenying, Niu, Xinxin, Huang, Mengmeng, Gao, Yulong, Liu, Aijing, Gao, Li, Li, Kai, Pan, Qing, Liu, Changjun, Zhang, Yanping, Cui, Hongyu, Wang, Xiaomei, Qi, Xiaole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671459/
https://www.ncbi.nlm.nih.gov/pubmed/34926638
http://dx.doi.org/10.3389/fvets.2021.759861
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author Jiang, Nan
Wang, Yulong
Zhang, Wenying
Niu, Xinxin
Huang, Mengmeng
Gao, Yulong
Liu, Aijing
Gao, Li
Li, Kai
Pan, Qing
Liu, Changjun
Zhang, Yanping
Cui, Hongyu
Wang, Xiaomei
Qi, Xiaole
author_facet Jiang, Nan
Wang, Yulong
Zhang, Wenying
Niu, Xinxin
Huang, Mengmeng
Gao, Yulong
Liu, Aijing
Gao, Li
Li, Kai
Pan, Qing
Liu, Changjun
Zhang, Yanping
Cui, Hongyu
Wang, Xiaomei
Qi, Xiaole
author_sort Jiang, Nan
collection PubMed
description Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which seriously threatens the healthy development of the poultry industry. Since its spread to China in the early 1990s, the very virulent IBDV (vvIBDV) characterized by high lethality, has been the focus of prevention and control. However, the novel variant IBDV (nVarIBDV), which has been widely prevalent in China since 2017, has brought a new threat to the poultry industry. In this study, the prevalence of IBDV in the important poultry-raising areas of China from 2019 to 2020 was detected. Of these, 45.1% (101/224) of the samples and 61.9% (26/42) of the chicken flocks were shown to be positive for IBDV. For 50 IBDVs, the sequences of the hypervariable region of the VP2 gene in segment A and of the B-marker of the VP1 gene in segment B were analyzed. The results revealed the coexistence of a number of different IBDV genotypes, including A2dB1 (nVar, 26/50, 52.0%), A3B3 (HLJ0504-like, 15/50, 30.0%), A1B1 (classical, 1/50, 2.0%), and A8B1 (attenuated, 1/50, 2.0%). This indicated that the newly emerging nVarIBDV of A2dB1 and the persistently circulating HLJ0504-like vvIBDV of A3B3 are the two important epidemic strains. Furthermore, we established that segment reassortment has occurred among these circulating strains. This study is the first to reveal the novel epidemic characteristics of IBDV since the report of the emerging nVarIBDV of A2dB1 in China.
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spelling pubmed-86714592021-12-16 Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020 Jiang, Nan Wang, Yulong Zhang, Wenying Niu, Xinxin Huang, Mengmeng Gao, Yulong Liu, Aijing Gao, Li Li, Kai Pan, Qing Liu, Changjun Zhang, Yanping Cui, Hongyu Wang, Xiaomei Qi, Xiaole Front Vet Sci Veterinary Science Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which seriously threatens the healthy development of the poultry industry. Since its spread to China in the early 1990s, the very virulent IBDV (vvIBDV) characterized by high lethality, has been the focus of prevention and control. However, the novel variant IBDV (nVarIBDV), which has been widely prevalent in China since 2017, has brought a new threat to the poultry industry. In this study, the prevalence of IBDV in the important poultry-raising areas of China from 2019 to 2020 was detected. Of these, 45.1% (101/224) of the samples and 61.9% (26/42) of the chicken flocks were shown to be positive for IBDV. For 50 IBDVs, the sequences of the hypervariable region of the VP2 gene in segment A and of the B-marker of the VP1 gene in segment B were analyzed. The results revealed the coexistence of a number of different IBDV genotypes, including A2dB1 (nVar, 26/50, 52.0%), A3B3 (HLJ0504-like, 15/50, 30.0%), A1B1 (classical, 1/50, 2.0%), and A8B1 (attenuated, 1/50, 2.0%). This indicated that the newly emerging nVarIBDV of A2dB1 and the persistently circulating HLJ0504-like vvIBDV of A3B3 are the two important epidemic strains. Furthermore, we established that segment reassortment has occurred among these circulating strains. This study is the first to reveal the novel epidemic characteristics of IBDV since the report of the emerging nVarIBDV of A2dB1 in China. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8671459/ /pubmed/34926638 http://dx.doi.org/10.3389/fvets.2021.759861 Text en Copyright © 2021 Jiang, Wang, Zhang, Niu, Huang, Gao, Liu, Gao, Li, Pan, Liu, Zhang, Cui, Wang and Qi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Jiang, Nan
Wang, Yulong
Zhang, Wenying
Niu, Xinxin
Huang, Mengmeng
Gao, Yulong
Liu, Aijing
Gao, Li
Li, Kai
Pan, Qing
Liu, Changjun
Zhang, Yanping
Cui, Hongyu
Wang, Xiaomei
Qi, Xiaole
Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title_full Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title_fullStr Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title_full_unstemmed Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title_short Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020
title_sort genotyping and molecular characterization of infectious bursal disease virus identified in important poultry-raising areas of china during 2019 and 2020
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671459/
https://www.ncbi.nlm.nih.gov/pubmed/34926638
http://dx.doi.org/10.3389/fvets.2021.759861
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